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You searched for +publisher:"Clemson University" +contributor:("Guigen Zhang, Committee Chair"). Showing records 1 – 2 of 2 total matches.

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Clemson University

1. Zhao, Yu. An Integrative Approach to Elucidating the Governing Mechanisms of Particles Movement under Dielectrophoretic and Other Electrokinetic Phenomena.

Degree: PhD, Bioengineering, 2017, Clemson University

Dielectrophoresis (DEP) has been a subject of active research in the past decades and has shown promising applications in Lab-on-Chip devices. Currently researchers use the point dipole method to predict the movement of particles under DEP and guide their experimental designs. For studying the interaction between particles, the Maxwell Stress Tensor (MST) method has been widely used and treated as providing the most robust and accurate solution. By examining the derivation processes, it became clear that both methods have inherent limitations and will yield incorrect results in certain occasions. To overcome these limitations and advance the theory of DEP, a new numerical approach based on volumetric-integration has been established. The new method has been proved to be valid in quantifying the DEP forces with both homogeneous and non-homogeneous particles as well as particle-particle interaction through comparison with the other two methods. Based on the new method, a new model characterizing the structure of electric double layer (EDL) was developed to explain the crossover behavior of nanoparticles in medium. For bioengineering applications, this new method has been further expanded to construct a complete cell model. The cell model not only captures the common crossover behavior exhibited by cells, it also explains why cells would initiate self-rotation under DEP, a phenomenon we first observed in our experiments. To take a step further, the new method has also been applied to investigate the interaction between multiple particles. In particular, this new method has been proved to be powerful in elucidating the underlying mechanism of the tumbling motion of pearl chains in a flow condition as we observed in our experiments. Moreover, it also helps shed some new insight into the formation of different alignments and configurations of ellipsoidal particles. Finally, with the consideration of the Faradic current from water electrolysis and effect of pH, a new model has been developed to explain the causes for the intriguing flow reversal phenomenon commonly observed (but not at all understood) in AC-electroosmosis (ACEO) with reasonable outcomes. Advisors/Committee Members: Dr. Guigen Zhang, Committee Chair, Dr. Bruce Gao, Dr. Rodrigo Martinez-Duarte, Dr. Xiangchun Xuan.

Subjects/Keywords: AC-electroosmosis; Dielectrophoresis; Electric double layer; Self-rotation of cell; Tumbling motion; Volumetric-integration method

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APA (6th Edition):

Zhao, Y. (2017). An Integrative Approach to Elucidating the Governing Mechanisms of Particles Movement under Dielectrophoretic and Other Electrokinetic Phenomena. (Doctoral Dissertation). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_dissertations/1956

Chicago Manual of Style (16th Edition):

Zhao, Yu. “An Integrative Approach to Elucidating the Governing Mechanisms of Particles Movement under Dielectrophoretic and Other Electrokinetic Phenomena.” 2017. Doctoral Dissertation, Clemson University. Accessed September 20, 2020. https://tigerprints.clemson.edu/all_dissertations/1956.

MLA Handbook (7th Edition):

Zhao, Yu. “An Integrative Approach to Elucidating the Governing Mechanisms of Particles Movement under Dielectrophoretic and Other Electrokinetic Phenomena.” 2017. Web. 20 Sep 2020.

Vancouver:

Zhao Y. An Integrative Approach to Elucidating the Governing Mechanisms of Particles Movement under Dielectrophoretic and Other Electrokinetic Phenomena. [Internet] [Doctoral dissertation]. Clemson University; 2017. [cited 2020 Sep 20]. Available from: https://tigerprints.clemson.edu/all_dissertations/1956.

Council of Science Editors:

Zhao Y. An Integrative Approach to Elucidating the Governing Mechanisms of Particles Movement under Dielectrophoretic and Other Electrokinetic Phenomena. [Doctoral Dissertation]. Clemson University; 2017. Available from: https://tigerprints.clemson.edu/all_dissertations/1956


Clemson University

2. Bearden, Samuel L. Manipulation of the Electrical Double Layer for Control and Sensing in a Solid State Nanopore.

Degree: PhD, Bioengineering, 2015, Clemson University

Nanopores have been explored with the goal of achieving non-functionalized, sub-molecular sensors, primarily with the purpose of producing fast, low-cost DNA sequencers. Because of the nanoscale volume within the nanopore structure, it is possible to isolate individual molecular and sub-molecular analytes. Nanopore DNA sequencing has remained elusive due to high noise levels and the challenge of obtaining single-nucleotide resolution. However, the complete electrical double layer within the nanopore is a key feature of fluid-nanopore interaction and has been neglected in previous studies. By exploring interactions with the electrical double layer in various nanopore systems, we characterize the material, electrical, and solution dependent properties of this structure and develop a new sensing technique. The overall goals of this project are development of a theoretically complete and useful model of the electrical double layer in a nanopore, development of a nanopore device capable of detecting and manipulating the electrical double layer, characterization of active nanofluidic control, and detection of molecular and double layer properties. By considering extensive numerical models along with experimental evaluation of the nanopore devices, we characterize the fluidic and sensor properties of the electrical double layer in a nanopore. The ability to interact with the electrochemical and structural properties of the fluid within a nanopore offers new avenues for molecular detection and manipulation. We find that the energetic balance between the nanopore surface potential and the distribution of charged species within the electrical double layer is the key relationship governing the operation of this type of device. A method of active control of the ionic conductance through the nanopore was developed, with complete gating and on-state modulation. A molecular sensing technique was developed by correlating changes to the electrochemical potential of the solution to the physical properties of molecular analytes. The theoretical and practical limits of the nanopore sensor were tested by implementing a new type of nanopore DNA sequencer. High accuracy DNA sequences were produced by combining the double layer potential and ionic current channels in parallel, along with extensive application of signal theory, digital signal processing, and machine learning techniques. Advisors/Committee Members: Guigen Zhang, Committee Chair, Stephen Foulger, Christopher Saski, Bruce Gao, Alexey Vertegel.

Subjects/Keywords: Biomedical Engineering and Bioengineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Bearden, S. L. (2015). Manipulation of the Electrical Double Layer for Control and Sensing in a Solid State Nanopore. (Doctoral Dissertation). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_dissertations/2085

Chicago Manual of Style (16th Edition):

Bearden, Samuel L. “Manipulation of the Electrical Double Layer for Control and Sensing in a Solid State Nanopore.” 2015. Doctoral Dissertation, Clemson University. Accessed September 20, 2020. https://tigerprints.clemson.edu/all_dissertations/2085.

MLA Handbook (7th Edition):

Bearden, Samuel L. “Manipulation of the Electrical Double Layer for Control and Sensing in a Solid State Nanopore.” 2015. Web. 20 Sep 2020.

Vancouver:

Bearden SL. Manipulation of the Electrical Double Layer for Control and Sensing in a Solid State Nanopore. [Internet] [Doctoral dissertation]. Clemson University; 2015. [cited 2020 Sep 20]. Available from: https://tigerprints.clemson.edu/all_dissertations/2085.

Council of Science Editors:

Bearden SL. Manipulation of the Electrical Double Layer for Control and Sensing in a Solid State Nanopore. [Doctoral Dissertation]. Clemson University; 2015. Available from: https://tigerprints.clemson.edu/all_dissertations/2085

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