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You searched for +publisher:"Clemson University" +contributor:("Dr. John D. DesJardins"). Showing records 1 – 2 of 2 total matches.

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Clemson University

1. Rogalski, Melissa M. Development of Position-Dependent Luminescent Sensors: Spectral Rulers and Chemical Sensing Through Tissue.

Degree: PhD, Chemistry, 2016, Clemson University

Assessing the performance of medical devices is critical for understanding device function and monitoring pathologies. With the use of a smart device clinically relevant chemical and mechanical information regarding fracture healing may be deduced. For example, strain on the device may be used as a mechanical indicator of weight-bearing capacity. In addition, changes in chemical environment may indicate the development of implant associated infections. Although optical methods are widely used for ex vivostrain/motion analysis and for chemical analyses in cells and histological tissue sections, there utility is limited through thick tissue because light scattering reduces spatial resolution. This dissertation presents four novel luminescent sensors that overcome this limitation. The sensors are capable of detecting chemical and physical changes by measuring position or orientation-dependent color/wavelength changes through tissue. The first three sensors are spectral rulers comprised of two patterned thin films: an encoder strip and an analyzer mask. The encoder strip is either a thin film patterned with stripes of alternating luminescent materials (quantum dots, particles or dyes) or a film containing alternating stripes of a dye that absorbs luminescence from a particle film placed below. The analyzer mask is patterned with a series of alternating transparent windows and opaque stripes equal in width to the encoder lines. The analyzer is overlaid upon the encoder strip such that displacement of the encoder relative to the analyzer modulates the color/spectrum visible through the windows. Relative displacement of the sensor layers is mechanically confined to a single axis. When the substrates are overlaid in the “home position” one line spectrum is observed, and in the “end position,” another line spectrum is observed. At intermediate positions, spectra are a linear combination of the “home” and “end” spectra. The position-modulated signal is collected by a spectrometer and a spectral intensity ratio from closely spaced emission peaks is calculated. By collecting luminescent spectra, rather than imaging the device surface, the sensors eliminate the need to spatially resolve small features through tissue by measuring displacement as a function of color. We measured micron scale displacements through at least 6 mm of tissue using three types of spectral ruler based upon 1) fluorescence, 2) x-ray excited optical luminescence (XEOL), and 3) near infrared upconversion luminescence. The sensors may be used to investigate strain on orthopedic implants, study interfragmentary motion, or assess tendon/ligament tears. In addition to monitoring mechanical strain it is important to investigate clinically relevant implant pathologies such as infection. To address this application, we have developed a fourth type of sensor. The sensor monitors changes in local pH, an indicator of biofilm formation, and uses magnetic fields to modulate position and orientation-dependent luminescence. This modulation allows the sensor signal to be… Advisors/Committee Members: Dr. Jeffrey N. Anker, Committee Chair, Dr. John D. DesJardins, Dr. George Chumanov, Dr. Joseph Kolis.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Rogalski, M. M. (2016). Development of Position-Dependent Luminescent Sensors: Spectral Rulers and Chemical Sensing Through Tissue. (Doctoral Dissertation). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_dissertations/1706

Chicago Manual of Style (16th Edition):

Rogalski, Melissa M. “Development of Position-Dependent Luminescent Sensors: Spectral Rulers and Chemical Sensing Through Tissue.” 2016. Doctoral Dissertation, Clemson University. Accessed November 25, 2020. https://tigerprints.clemson.edu/all_dissertations/1706.

MLA Handbook (7th Edition):

Rogalski, Melissa M. “Development of Position-Dependent Luminescent Sensors: Spectral Rulers and Chemical Sensing Through Tissue.” 2016. Web. 25 Nov 2020.

Vancouver:

Rogalski MM. Development of Position-Dependent Luminescent Sensors: Spectral Rulers and Chemical Sensing Through Tissue. [Internet] [Doctoral dissertation]. Clemson University; 2016. [cited 2020 Nov 25]. Available from: https://tigerprints.clemson.edu/all_dissertations/1706.

Council of Science Editors:

Rogalski MM. Development of Position-Dependent Luminescent Sensors: Spectral Rulers and Chemical Sensing Through Tissue. [Doctoral Dissertation]. Clemson University; 2016. Available from: https://tigerprints.clemson.edu/all_dissertations/1706

2. Joshi, Shraddha. Understanding the Role of Requirements in Engineering Design by Novices.

Degree: PhD, Mechanical Engineering, 2013, Clemson University

Requirements play a critical role in the design process. The broader impact of this research is to develop a systematic understanding of the current use of requirements with an ultimate goal to develop guidelines and recommendations for more effective use of requirements throughout the design process. Thus, this research begins to answer the question about what is the role of requirements in design process and, specifically, its role in idea generation? The answer to this question is explored in three phases. The first phase is to understand how requirements are currently taught to students. To that end, two surveys were conducted. First, a review of ten design textbooks was conducted as an initial surrogate for understanding what is formally taught. This was done to understand the use of requirements within the design tools mentioned in the textbooks. Supplementing this, interviews of faculty involved in teaching design courses was conducted with faculty from mechanical engineering, industrial engineering, bioengineering, and materials science and engineering. While the interviews suggest that the use of requirements is distributed throughout the design process, in agreement with common practice, the instruction provided students, based on the survey of textbooks, focuses on requirements tools found exclusively in the conceptual design phase. Thus, a significant gap is identified in terms of lack of sufficient tools explaining the use of requirements. In order to understand the consequences of lack of tools and to develop a deeper understanding of how students are applying the requirements education imparted to them, a case study analysis was conducted with senior mechanical engineering design students in a capstone course. Data was collected from four teams working in parallel on the same design project in form of requirements documents from initial weeks and the final report deliverable. The findings from this study reveal that there is lack of uniformity in how students elicit requirements in the initial weeks of the project. The completeness and specificity of requirements increase from the initial weeks to the final week, as expected, as the students develop a better understanding of the problem. However, in terms of addressing the requirements, more requirements with one adjunct or numerical value, and thus low specificity, were addressed. Further, it was found that the requirements documents of novice designers (students) change in multiple ways. Currently, the students do not have tools or methods in place that would allow them to systematically manage the changes in requirements document. Finally, as a deeper dive into how requirements can impact a specific design activity, an empirical designer study was conducted to explore the impact of requirements elicitation in idea generation. The study was conducted, again, with senior mechanical engineering students at Clemson University. The findings from the experimental study suggest that the students elicit more non-functional requirements compared to… Advisors/Committee Members: Dr. Joshua D. Summers, Dr. John D. DesJardins, Dr. Georges M. Fadel, Dr. Gregory M. Mocko.

Subjects/Keywords: Case Study; Designer Study; Ideation; Novice designers; Requirements; Requirements tracing; Mechanical Engineering

…of people in mechanical engineering department at Clemson University helped me great deal… …my stay at Clemson University. Finally, I want to thank you Clemson for being my home for… …Research in CEDAR Researchers within CEDAR lab at Clemson University have made significant… …RQ2, a case study was conducted with senior design students at Clemson University. Chapter… …end, a designer study was conducted with senior design students at Clemson University… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Joshi, S. (2013). Understanding the Role of Requirements in Engineering Design by Novices. (Doctoral Dissertation). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_dissertations/1254

Chicago Manual of Style (16th Edition):

Joshi, Shraddha. “Understanding the Role of Requirements in Engineering Design by Novices.” 2013. Doctoral Dissertation, Clemson University. Accessed November 25, 2020. https://tigerprints.clemson.edu/all_dissertations/1254.

MLA Handbook (7th Edition):

Joshi, Shraddha. “Understanding the Role of Requirements in Engineering Design by Novices.” 2013. Web. 25 Nov 2020.

Vancouver:

Joshi S. Understanding the Role of Requirements in Engineering Design by Novices. [Internet] [Doctoral dissertation]. Clemson University; 2013. [cited 2020 Nov 25]. Available from: https://tigerprints.clemson.edu/all_dissertations/1254.

Council of Science Editors:

Joshi S. Understanding the Role of Requirements in Engineering Design by Novices. [Doctoral Dissertation]. Clemson University; 2013. Available from: https://tigerprints.clemson.edu/all_dissertations/1254

.