+publisher:"Clemson University" +contributor:("Dr. Ethan Kung")

Clemson University

1. Wright, James Ray, III. Static Pressure Recovery Effects of Conical Diffusers with Swirling Inlet Flow.

Degree: MS, Mechanical Engineering, 2020, Clemson University

URL: https://tigerprints.clemson.edu/all_theses/3363

► Conical diffusers are used in hundreds of engineering applications in various industries. Some of the operating conditions that they operate under cause swirling flow… (more)

Subjects/Keywords: Mechanical Engineering

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wright, James Ray, I. (2020). Static Pressure Recovery Effects of Conical Diffusers with Swirling Inlet Flow. (Masters Thesis). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_theses/3363

Chicago Manual of Style (16^th Edition):

Wright, James Ray, III. “Static Pressure Recovery Effects of Conical Diffusers with Swirling Inlet Flow.” 2020. Masters Thesis, Clemson University. Accessed January 25, 2021. https://tigerprints.clemson.edu/all_theses/3363.

MLA Handbook (7^th Edition):

Wright, James Ray, III. “Static Pressure Recovery Effects of Conical Diffusers with Swirling Inlet Flow.” 2020. Web. 25 Jan 2021.

Vancouver:

Wright, James Ray I. Static Pressure Recovery Effects of Conical Diffusers with Swirling Inlet Flow. [Internet] [Masters thesis]. Clemson University; 2020. [cited 2021 Jan 25]. Available from: https://tigerprints.clemson.edu/all_theses/3363.

Council of Science Editors:

Wright, James Ray I. Static Pressure Recovery Effects of Conical Diffusers with Swirling Inlet Flow. [Masters Thesis]. Clemson University; 2020. Available from: https://tigerprints.clemson.edu/all_theses/3363

Clemson University

2. Farahmand, Masoud. Cavopulmonary Support for Failing Fontan Patients: Computational and In Vitro Assessment.

Degree: PhD, Mechanical Engineering, 2019, Clemson University

URL: https://tigerprints.clemson.edu/all_dissertations/2571

► Congenital heart defects are responsible for the mortality of approximately 300,000 newborn each year. One study in 2010 estimated that over 2 million patients… (more)

▼ Congenital heart defects are responsible for the mortality of approximately 300,000 newborn each year. One study in 2010 estimated that over 2 million patients were living with congenital heart defects in the United States. Congenital heart defects have the highest hospitalization cost among other birth defect categories. The damage on the U.S economy in 2013 was estimated $6.1 billion. The most complex and severe form of these defects results in single ventricle physiology. Fortunately, over the last 50 years, these patients have been able to survive into adulthood as a result of three stages of surgeries culminating with Fontan operation. However, Fontan operation as the current ultimate palliation of single ventricle defects results in significant late complications. Fontan patients will eventually develop circulatory failure and are in desperate need of an immediate therapeutic solution. A rightsided device surgically placed in the cavopulmonary pathway could technically substitute the missing sub-pulmonary ventricle by generating a mild pressure boost. However, currently, there is no device specifically designed for this application due to the small market size. On the other hand, off-label use of an arterial pump (originally designed for left side application) for the cavopulmonary support remains challenging. This is because the hemodynamic impact of a ventricular assist device (VAD) implanted on the right circulation of a Fontan patient is not yet clear. Moreover, further research is needed to identify the physiological consequences of two clinically-considered surgical configurations (IVC and full assisted configurations) for the cavopulmonary VAD installation, with full and IVC support corresponding to the entire venous return or only the inferior venous return, respectively, being routed through the VAD. First objective of this thesis is surgical planning to accurately predict the outcome of cavopulmonary support in failing Fontan patients and findings of this study will help the surgeons in developing coherent clinical strategies for the cavopulmonary support implementation and tuning. Specific objective 2 will investigate the desired operating region for designing a cavopulmonary blood pump that can offer a promising alternative treatment option for a wide range of failing Fontan patients. Advisors/Committee Members: Dr. Ethan Kung, Committee Chair, Dr. Richard Figliola, Dr. Joshua Bostwick, Dr. Gregory Mocko.

Subjects/Keywords: Mechanical Engineering

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Farahmand, M. (2019). Cavopulmonary Support for Failing Fontan Patients: Computational and In Vitro Assessment. (Doctoral Dissertation). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_dissertations/2571

Chicago Manual of Style (16^th Edition):

Farahmand, Masoud. “Cavopulmonary Support for Failing Fontan Patients: Computational and In Vitro Assessment.” 2019. Doctoral Dissertation, Clemson University. Accessed January 25, 2021. https://tigerprints.clemson.edu/all_dissertations/2571.

MLA Handbook (7^th Edition):

Farahmand, Masoud. “Cavopulmonary Support for Failing Fontan Patients: Computational and In Vitro Assessment.” 2019. Web. 25 Jan 2021.

Vancouver:

Farahmand M. Cavopulmonary Support for Failing Fontan Patients: Computational and In Vitro Assessment. [Internet] [Doctoral dissertation]. Clemson University; 2019. [cited 2021 Jan 25]. Available from: https://tigerprints.clemson.edu/all_dissertations/2571.

Council of Science Editors:

Farahmand M. Cavopulmonary Support for Failing Fontan Patients: Computational and In Vitro Assessment. [Doctoral Dissertation]. Clemson University; 2019. Available from: https://tigerprints.clemson.edu/all_dissertations/2571

3. Kalkhanda, Abhinav. Joule Heating Enabled Electrokinetic Trapping of Submicron Particles in Ratchet Microchannels Using Depth Modelling.

Degree: MS, Mechanical Engineering, 2017, Clemson University

URL: https://tigerprints.clemson.edu/all_theses/2704

► Microfluidic devices have been increasingly used for diverse particle manipulations in various chemical and biological applications. Fields such as water quality control, environmental monitoring and… (more)

▼ Microfluidic devices have been increasingly used for diverse particle manipulations in various chemical and biological applications. Fields such as water quality control, environmental monitoring and food safety require the continuous trapping and concentration of particles (either bio- or non-bio) for enhanced detection and analysis. To achieve this, various microfluidic techniques have been developed using electric field as well as other fields including magnetic, optical, acoustic, hydrodynamic, gravitational and inertial. Among these methods, electrokinetic manipulation of particles is the most often used due to its advantages over other methods such as simple operation and easy integration etc. It transports fluids and controls the motion of the suspended particles via electroosmosis, electrophoresis and dielectrophoresis. However, there is an inevitable phenomenon accompanying electrokinetic devices, i.e., Joule heating due to the passage of electric current through the conductive suspending medium. Previous studies indicate a negative impact of Joule heating on the trapping and concentration of micron-sized particles in insulator-based dielectrophoretic microdevices. We demonstrate in this thesis that the Joule heating-induced electrothermal flow can actually enhance the electrokinetic manipulation, leading to the otherwise impossible trapping and concentration of submicron particles in ratchet microchannels. We fabricated ratchet microchannels with polydimethylsiloxane and used them to study the transport and control of submicron particles in a moderately conductive phosphate buffer solution. Our research group did the experiments previously. We developed a numerical multiphysics depth average model, which can predict the observed particle trapping in the ratchet region. The numerical model consists of coupled electric current, fluid flow, heat transfer and mass transport equation. A depth average analysis of these governing equations was done to develop a 2D model on the horizontal plane of the microchannel, which gives us numerical results that are as good as a full-scale 3D model developed previously, but with much less computational resources. Numerical analysis of the developed model predicts the formation of two counter rotating electrothermal vortices at the ratchet tips. Moreover, particles can be seen trapped inside these vortices and the concentration of particles trapped in electrothermal vortices can be observed to increase with time. Further, on doing the parametric study we found out that with increase in voltage the size of these vortices increases. We also changed the shape of the ratchet, but that does not seem to affect particle trapping in a significant manner. These obtained numerically predicted results are found to be in good agreement with our experimental observations, which further validates our numerical modelling. Advisors/Committee Members: Dr. Xiangchun Xuan, Committee Chair, Dr. Xin Zhao, Dr. Ethan Kung.

Subjects/Keywords: Joule heating; Microfluidics

10 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kalkhanda, A. (2017). Joule Heating Enabled Electrokinetic Trapping of Submicron Particles in Ratchet Microchannels Using Depth Modelling. (Masters Thesis). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_theses/2704

Chicago Manual of Style (16^th Edition):

Kalkhanda, Abhinav. “Joule Heating Enabled Electrokinetic Trapping of Submicron Particles in Ratchet Microchannels Using Depth Modelling.” 2017. Masters Thesis, Clemson University. Accessed January 25, 2021. https://tigerprints.clemson.edu/all_theses/2704.

MLA Handbook (7^th Edition):

Kalkhanda, Abhinav. “Joule Heating Enabled Electrokinetic Trapping of Submicron Particles in Ratchet Microchannels Using Depth Modelling.” 2017. Web. 25 Jan 2021.

Vancouver:

Kalkhanda A. Joule Heating Enabled Electrokinetic Trapping of Submicron Particles in Ratchet Microchannels Using Depth Modelling. [Internet] [Masters thesis]. Clemson University; 2017. [cited 2021 Jan 25]. Available from: https://tigerprints.clemson.edu/all_theses/2704.

Council of Science Editors:

Kalkhanda A. Joule Heating Enabled Electrokinetic Trapping of Submicron Particles in Ratchet Microchannels Using Depth Modelling. [Masters Thesis]. Clemson University; 2017. Available from: https://tigerprints.clemson.edu/all_theses/2704

4. Sudarsanam, Senbagaraman. Particle Manipulation in Viscous Flows: Singularity Models and Phase Space Boundaries.

Degree: PhD, Mechanical Engineering, 2018, Clemson University

URL: https://tigerprints.clemson.edu/all_dissertations/2181

► This dissertation develops a modeling framework to address the problem of particle manipulation in low Reynolds number fluid flows. This framework combines singularity methods in… (more)

Subjects/Keywords: Chaos; Dynamical systems; Inertial Particles; Microfluidics; Mixing; Singularity methods

10 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sudarsanam, S. (2018). Particle Manipulation in Viscous Flows: Singularity Models and Phase Space Boundaries. (Doctoral Dissertation). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_dissertations/2181

Chicago Manual of Style (16^th Edition):

Sudarsanam, Senbagaraman. “Particle Manipulation in Viscous Flows: Singularity Models and Phase Space Boundaries.” 2018. Doctoral Dissertation, Clemson University. Accessed January 25, 2021. https://tigerprints.clemson.edu/all_dissertations/2181.

MLA Handbook (7^th Edition):

Sudarsanam, Senbagaraman. “Particle Manipulation in Viscous Flows: Singularity Models and Phase Space Boundaries.” 2018. Web. 25 Jan 2021.

Vancouver:

Sudarsanam S. Particle Manipulation in Viscous Flows: Singularity Models and Phase Space Boundaries. [Internet] [Doctoral dissertation]. Clemson University; 2018. [cited 2021 Jan 25]. Available from: https://tigerprints.clemson.edu/all_dissertations/2181.

Council of Science Editors:

Sudarsanam S. Particle Manipulation in Viscous Flows: Singularity Models and Phase Space Boundaries. [Doctoral Dissertation]. Clemson University; 2018. Available from: https://tigerprints.clemson.edu/all_dissertations/2181

5. Schmidt, Tyler Matthew. Computational Evaluation of Ventricular Assist Device Implementation in the Single Ventricle Circulation.

Degree: MS, Mechanical Engineering, 2016, Clemson University

URL: https://tigerprints.clemson.edu/all_theses/2590

► Patients with a single ventricle congenital heart defect are prone to increased volume loading, which can lead to heart failure and require mechanical circulatory… (more)

▼ Patients with a single ventricle congenital heart defect are prone to increased volume loading, which can lead to heart failure and require mechanical circulatory support. A ventricular assist device (VAD) can serve as a bridge treatment option for these patients. However, in VAD support cases, pediatric patients possessing congenital heart defects have lower survival rates than patients without and outcomes worsen further in single ventricle cases. Performance differences between pulsatile and continuous flow VADs have also been clinically observed, but the underlying mechanism remains poorly understood. Six pediatric, stage 1 single ventricle patients (cohort mean BSA = 0.30 m2) were considered. The cardiovascular system was computationally simulated using a lumped-parameter network (LPN) tuned to patient specific data. A first set of simulations emulated current clinical implementation of VADs in single ventricle patients. A second set modified VAD settings with the goal to further improve cardiac output (CO). For all patients, optimal CO was at least 1 L min-1 greater with the continuous flow VAD compared that of pulsatile flow (p=0.0009). The 25 and 50 mL pulsatile flow VADs exhibited incomplete filling at higher heart rates that reduced CO as much as 0.26 and 1.4 L min-1 (9.7% and 37.3%) below design expectations respectively. Optimization of pulsatile flow VAD settings to improve filling did not achieve statistically significant (p<0.05) improvement. Results corroborate anecdotal clinical experience associating continuous flow VADs with superior CO and ventricular unloading in single ventricle patients. Future work should aim to improve models for ventricular suction resistance and the passive pressure-volume relationship at negative ventricular pressures. As part of future work, the single ventricle LPN was modified to simulate resting and exercise physiologies of example adult patients with normal bi-ventricular circulations. Correlations with exercise level for key physiological parameters were developed using prior literature data. Considerations for patient fitness level and age were also incorporated as appropriate. This model produced resting physiology within tolerance of prior literature data and exercise physiologies for two example patients within 10% of prior data for CO and mean arterial pressure. This modified LPN serves as a platform for future work in computational studies of bi-ventricular patients. Advisors/Committee Members: Dr. Ethan Kung, Committee Chair, Dr. Ravikiran Singapogu, Dr. Phanindra Tallapragada.

11 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schmidt, T. M. (2016). Computational Evaluation of Ventricular Assist Device Implementation in the Single Ventricle Circulation. (Masters Thesis). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_theses/2590

Chicago Manual of Style (16^th Edition):

Schmidt, Tyler Matthew. “Computational Evaluation of Ventricular Assist Device Implementation in the Single Ventricle Circulation.” 2016. Masters Thesis, Clemson University. Accessed January 25, 2021. https://tigerprints.clemson.edu/all_theses/2590.

MLA Handbook (7^th Edition):

Schmidt, Tyler Matthew. “Computational Evaluation of Ventricular Assist Device Implementation in the Single Ventricle Circulation.” 2016. Web. 25 Jan 2021.

Vancouver:

Schmidt TM. Computational Evaluation of Ventricular Assist Device Implementation in the Single Ventricle Circulation. [Internet] [Masters thesis]. Clemson University; 2016. [cited 2021 Jan 25]. Available from: https://tigerprints.clemson.edu/all_theses/2590.

Council of Science Editors:

Schmidt TM. Computational Evaluation of Ventricular Assist Device Implementation in the Single Ventricle Circulation. [Masters Thesis]. Clemson University; 2016. Available from: https://tigerprints.clemson.edu/all_theses/2590

6. Yeomans, Kyle Benjamin. In Vitro Study on the Viability for Use of 3D Printed Valves for Treatment of Chronic Venous Insufficiency.

Degree: MS, Mechanical Engineering, 2018, Clemson University

URL: https://tigerprints.clemson.edu/all_theses/2894

► Chronic venous insufficiency (CVI) is a medical disease caused as a result of incompetent vein valves in the lower extremities by the failure to reduce… (more)

▼ Chronic venous insufficiency (CVI) is a medical disease caused as a result of incompetent vein valves in the lower extremities by the failure to reduce venous pressure during calf exercise. This condition affects 2.5 million individuals in the United States; some estimates are over 6 million due to undiagnosed cases. Healthy venous flow is characterized by the calf muscle producing a lower venous pressure with competent vein valves maintaining this reduced pressure by preventing blood from flowing back into the lower legs; instead of returning to the heart. Conversely, an individual suffering from CVI has partially or fully incompetent vein valves which allow retrograde blood flow. The symptoms from the disease can range from a minor case in which blood pools in the feet, causing swelling and discomfort, to more severe cases including venous ulcers; potentially leading to disability for patients. Treatment options for patients with less severe cases include compression sleeves for the affected areas, exercise, medication, and some minimally invasive, outpatient procedures. Unfortunately, the only medical alternatives if these treatments prove to be ineffective include more aggressive interventions to attempt to repair, replace, or transplant new valves to the affected area; however, these procedures can be technically difficult to perform and are not always effective. Another option for treatment of CVI that has seen improvement over recent years is the manufacturing of prosthetic vein valves for implantation into individuals; one of which is using 3-D printing technology to produce bio-compatible valves composed of a PEGDA pre-polymer solution. In order to test the concept of this approach and to improve the effective design of these valves, an experimental flow loop derived from a lumped parameter model of the leg venous system was used. The resting pressure of the system was set to one-half that of the adult pressures due to the presently available gel material used for the printing of the valves is inadequate. The system was tuned to match the physiological ankle pressure response during exercise by the adjustment of specific system parameters to match the ambulatory venous pressure and recovery time criteria. An ideal venous valve was first tested as a controlled baseline, and the 3-D printed valves were then tested for utility. Valves were then tested for the appropriate ambulatory venous pressure response to verify if the tested valves met the desired physiological criteria. Additionally, a sample of valves was statistically analyzed to offer information on the capability of the valves, to assess the consistency in valve printing, and to determine the life cycle of the valves during continuous use. A Weibull distribution analysis was performed to draw conclusions on the life cycle test results. In conclusion, the tests showed that the 3-D printed valves are able to satisfy the desired pressure-related parameters of time to ambulatory venous pressure, mean ambulatory venous pressure, and recovery time… Advisors/Committee Members: Dr. Richard Figliola, Committee Chair, Dr. Donald Beasley, Dr. Ethan Kung.

10 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yeomans, K. B. (2018). In Vitro Study on the Viability for Use of 3D Printed Valves for Treatment of Chronic Venous Insufficiency. (Masters Thesis). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_theses/2894

Chicago Manual of Style (16^th Edition):

Yeomans, Kyle Benjamin. “In Vitro Study on the Viability for Use of 3D Printed Valves for Treatment of Chronic Venous Insufficiency.” 2018. Masters Thesis, Clemson University. Accessed January 25, 2021. https://tigerprints.clemson.edu/all_theses/2894.

MLA Handbook (7^th Edition):

Yeomans, Kyle Benjamin. “In Vitro Study on the Viability for Use of 3D Printed Valves for Treatment of Chronic Venous Insufficiency.” 2018. Web. 25 Jan 2021.

Vancouver:

Yeomans KB. In Vitro Study on the Viability for Use of 3D Printed Valves for Treatment of Chronic Venous Insufficiency. [Internet] [Masters thesis]. Clemson University; 2018. [cited 2021 Jan 25]. Available from: https://tigerprints.clemson.edu/all_theses/2894.

Council of Science Editors:

Yeomans KB. In Vitro Study on the Viability for Use of 3D Printed Valves for Treatment of Chronic Venous Insufficiency. [Masters Thesis]. Clemson University; 2018. Available from: https://tigerprints.clemson.edu/all_theses/2894

7. Zhou, Jian. In Vitro Multi Scale Models to Study the Early Stage Circulations for Single Ventricle Heart Diseases Palliations.

Degree: PhD, Mechanical Engineering, 2016, Clemson University

URL: https://tigerprints.clemson.edu/all_dissertations/1632

► Single ventricle physiology can result from various congenital heart defects in which the patient has only one functional ventricle. Hypoplastic left heart syndrome refers to… (more)

▼ Single ventricle physiology can result from various congenital heart defects in which the patient has only one functional ventricle. Hypoplastic left heart syndrome refers to patients born with an underdeveloped left ventricle. A three stage palliation strategy is applied over the first several years of life to establish a viable circulation path using the one functioning ventricle. Results of the first stage Norwood procedure on neonates with hypoplastic left heart syndrome are unsatisfactory with high morbidities and mortalities primarily due to high ventricle load and other complications. An early second stage Bidirectional Glenn (BDG) procedure is not a suitable option for neonates due to their high pulmonary vascular resistance (PVR), which limits pulmonary blood flow. Realistic experimental models of these circulations are not well established and would be useful for studying the physiological response to surgical decisions on the distribution of flows to the various territories, so as to predict clinical hemodynamics and guide clinical planning. These would serve well to study novel intervention strategies and the effects of known complications at the local and systems-level. This study proved the hypothesis that it is possible to model accurately the first and second stage palliation circulations using multi-scale in vitro circulation models and to use these models to test novel surgical strategies while including the effects of possible complications. A multi-scale mock circulatory system (MCS), which couples a lumped parameter network model (LPN) of the neonatal circulation with an anatomically accurate three-dimensional model of the surgical anastomosis site, was built to simulate the hemodynamic performance of both the Stage 1 and Stage 2 circulations. A pediatric ventricular assist device was used as the single ventricle and a respiration model was applied to the Stage 2 circulation system. Resulting parameters measured were pressure and flow rates within the various territories, and systemic oxygen delivery (OD) were calculated. The Stage 1 and Stage 2 systems were validated by direct comparisons of time-based and mean pressures and flow rates between the experimental measurements, available clinical recordings and/or CFD simulations. Regression and correlation analyses and unpaired t-tests showed that there was excellent agreement between the clinical and experimental time-based results as measured throughout the circulations (0.60 < R² < 0.99; p > 0.05, r.m.s error< 5%). A novel, potentially alternative surgical strategy for the initial palliation, was proposed and was tested, called the assisted bidirectional Glenn (ABG) procedure. The approach taps the higher potential energy of the systemic circulation through a systemic to caval shunt with nozzle to increase pulmonary blood flow and oxygen delivery within a superior cavopulmonary connection. Experimental model was validated against a numerical model (0.65 < sigma < 0.97; p > 0.05). The tested results demonstrated the ABG… Advisors/Committee Members: Dr. Richard Figliola, Committee Chair, Dr. Donald Beasley, Dr. Chenning Tong, Dr. Ethan Kung.

Subjects/Keywords: Assisted Bidirectional Glenn; In vitro; Norwood; Palliation; Simulation; Single Ventricle Heart Disease

15 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhou, J. (2016). In Vitro Multi Scale Models to Study the Early Stage Circulations for Single Ventricle Heart Diseases Palliations. (Doctoral Dissertation). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_dissertations/1632

Chicago Manual of Style (16^th Edition):

Zhou, Jian. “In Vitro Multi Scale Models to Study the Early Stage Circulations for Single Ventricle Heart Diseases Palliations.” 2016. Doctoral Dissertation, Clemson University. Accessed January 25, 2021. https://tigerprints.clemson.edu/all_dissertations/1632.

MLA Handbook (7^th Edition):

Zhou, Jian. “In Vitro Multi Scale Models to Study the Early Stage Circulations for Single Ventricle Heart Diseases Palliations.” 2016. Web. 25 Jan 2021.

Vancouver:

Zhou J. In Vitro Multi Scale Models to Study the Early Stage Circulations for Single Ventricle Heart Diseases Palliations. [Internet] [Doctoral dissertation]. Clemson University; 2016. [cited 2021 Jan 25]. Available from: https://tigerprints.clemson.edu/all_dissertations/1632.

Council of Science Editors:

Zhou J. In Vitro Multi Scale Models to Study the Early Stage Circulations for Single Ventricle Heart Diseases Palliations. [Doctoral Dissertation]. Clemson University; 2016. Available from: https://tigerprints.clemson.edu/all_dissertations/1632

8. Bickford, Phoebe. Understanding the Expenditure and Recovery of Anaerobic Work Capacity Using Noninvasive Sensors.

Degree: MS, Mechanical Engineering, 2016, Clemson University

URL: https://tigerprints.clemson.edu/all_theses/2488

► The objective of this research is to advance the understanding of human performance to allow for optimized efforts on specific tasks. This is accomplished by… (more)

▼ The objective of this research is to advance the understanding of human performance to allow for optimized efforts on specific tasks. This is accomplished by 1) understanding the expenditure and recovery of Anaerobic Work Capacity (AWC) as related to the Critical Power (CP) of a human, and 2) determining if and how a case for an energy-management system to optimize energy expenditure and recovery can be made in real-time using noninvasive sensors. As humans exert energy, the body converts fuel into mechanical power through both aerobic and anaerobic energy systems. The mechanical power produced can be measured through the use of a cycle ergometer and the use of the energy systems can be measured by observing biological artifacts with sensors. There is a Critical Power level that a human can theoretically operate at indefinitely and there is a well-established theory in the literature to predict the depletion of a human’s finite Anaerobic Work Capacity based on this Critical Power. The literature however lacks a robust model for understanding the recovery of the Anaerobic Work Capacity. Because of this, a cycling study was conducted with ten regularly-exercising subjects (9 male, 1 female aged 23-44). First, the CP and AWC of the subjects were determined by a 3-minute all-out intensity cycling test. The subjects performed several interval protocols to exhaustion with recovery intervals to quantify how much AWC was recovered in each interval. Results: It was determined that sub-Critical Power recovery is not proportional to above-Critical Power expenditure. The amount of AWC recovered is influenced more by the power level held during recovery than the amount of time spent in recovery. The following conclusions are discussed in this thesis: 1) relationships between measurable biological artifacts and biological processes that are proven to exist in the literature; 2) expenditure and recovery of Anaerobic Work Capacity; 3) methods to use real-time, noninvasive sensor data to determine the status of human work capacity; and 4) how the results can be used in a human-in-the-loop feedback control system to optimize performance for a given task. Advisors/Committee Members: Dr. Gregory Mocko, Committee Chair, Dr. Ardalan Vahidi, Committee Member, Dr. Ethan Kung, Committee Member.

14 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bickford, P. (2016). Understanding the Expenditure and Recovery of Anaerobic Work Capacity Using Noninvasive Sensors. (Masters Thesis). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_theses/2488

Chicago Manual of Style (16^th Edition):

Bickford, Phoebe. “Understanding the Expenditure and Recovery of Anaerobic Work Capacity Using Noninvasive Sensors.” 2016. Masters Thesis, Clemson University. Accessed January 25, 2021. https://tigerprints.clemson.edu/all_theses/2488.

MLA Handbook (7^th Edition):

Bickford, Phoebe. “Understanding the Expenditure and Recovery of Anaerobic Work Capacity Using Noninvasive Sensors.” 2016. Web. 25 Jan 2021.

Vancouver:

Bickford P. Understanding the Expenditure and Recovery of Anaerobic Work Capacity Using Noninvasive Sensors. [Internet] [Masters thesis]. Clemson University; 2016. [cited 2021 Jan 25]. Available from: https://tigerprints.clemson.edu/all_theses/2488.

Council of Science Editors:

Bickford P. Understanding the Expenditure and Recovery of Anaerobic Work Capacity Using Noninvasive Sensors. [Masters Thesis]. Clemson University; 2016. Available from: https://tigerprints.clemson.edu/all_theses/2488

9. Carter, Lauren Elizabeth. The Coronary Circulation in an In Vitro Multi-Scale Model of the Stage 1 Norwood Procedure.

Degree: MS, Mechanical Engineering, 2016, Clemson University

URL: https://tigerprints.clemson.edu/all_theses/2540

► Hypoplastic Left Heart Syndrome (HLHS) is a congenital heart disease where the left ventricle and ascending aorta are underdeveloped. The first of three palliative surgeries… (more)

▼ Hypoplastic Left Heart Syndrome (HLHS) is a congenital heart disease where the left ventricle and ascending aorta are underdeveloped. The first of three palliative surgeries for this malformation is the Norwood procedure. In this surgery, an opening is made between the left and right atrium so that all blood can flow into the right ventricle (RV). A reconstructed aorta is anastomosed (connected) to the RV so that the RV can pump oxygenated blood to the body (the systemic circulation). To divert part of the systemic blood flow to the pulmonary circulation, the modified Blalock-Taussig Shunt (mBTS) is connected from the innominate artery to the pulmonary artery. However, Norwood patients with an mBTS may experience retrograde flow from the coronary circulation (which supplies blood to the heart) to the pulmonary circulation via the mBTS. This shunt steal of coronary blood can lead to detrimental issues such as myocardial ischemia leading to right ventricular dysfunction. In this study, a multi-scale model of the Norwood procedure couples a three-dimensional (3D) test section of the reconstructed aortic arch with a lumped parameter network (LPN) describing the Norwood patient's global hemodynamics. Previously, only in silico multi-scale models of the Norwood circulation have modeled the coronary circulation and the effects of varying mBTS sizes on coronary perfusion. Here, a novel in vitro coronary circulation model is adapted from such in silico studies and implemented into a previously validated in vitro mock circulatory system (MCS) of the Norwood with mBTS palliation. The MCS was verified against an analytical model and validated using a patient-specific test section and data. A parametric test in which the size of the mBTS inner diameter was varied from 3mm to 4mm was performed. The results showed that increasing mBTS size results in decreased diastolic aortic pressure, which decreases coronary blood flow (CBF) during diastole. Advisors/Committee Members: Dr. Richard Figliola, Committee Chair, Dr. Donald Beasley, Committee Member, Dr. Tiffany Camp, Committee Member, Dr. Ethan Kung, Committee Member.

…with permission of Dr. Tim Conover of Clemson University. ................. 99 xv…

11 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carter, L. E. (2016). The Coronary Circulation in an In Vitro Multi-Scale Model of the Stage 1 Norwood Procedure. (Masters Thesis). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_theses/2540

Chicago Manual of Style (16^th Edition):

Carter, Lauren Elizabeth. “The Coronary Circulation in an In Vitro Multi-Scale Model of the Stage 1 Norwood Procedure.” 2016. Masters Thesis, Clemson University. Accessed January 25, 2021. https://tigerprints.clemson.edu/all_theses/2540.

MLA Handbook (7^th Edition):

Carter, Lauren Elizabeth. “The Coronary Circulation in an In Vitro Multi-Scale Model of the Stage 1 Norwood Procedure.” 2016. Web. 25 Jan 2021.

Vancouver:

Carter LE. The Coronary Circulation in an In Vitro Multi-Scale Model of the Stage 1 Norwood Procedure. [Internet] [Masters thesis]. Clemson University; 2016. [cited 2021 Jan 25]. Available from: https://tigerprints.clemson.edu/all_theses/2540.

Council of Science Editors:

Carter LE. The Coronary Circulation in an In Vitro Multi-Scale Model of the Stage 1 Norwood Procedure. [Masters Thesis]. Clemson University; 2016. Available from: https://tigerprints.clemson.edu/all_theses/2540

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations