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You searched for +publisher:"California State University – San Marcos" +contributor:("Trujillo, Keith A"). One record found.

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1. Klumph, Marianne. Impact of Sensitization During Adolescence on Subsequent Drug Response: A Study of Resensitization .

Degree: 2013, California State University – San Marcos

Adolescents and young adults are the primary consumers of drugs of abuse (including prescriptions drugs); yet, most of the preclinical research aimed at understanding the effects of these drugs has been performed in adult animal models. Drug use during adolescence is particularly problematic because it is a major predictor of later drug abuse and dependence during adulthood. Although there is growing evidence for age differences in behavioral responses to drugs of abuse in rats, the long lasting impact of drug exposure has rarely been investigated using adolescent rats. Repeated exposure to a wide range of drugs has been shown to produce an enduring change in behavior termed sensitization. Behavioral sensitization refers to the progressive increase in the psychomotor effects of drugs following repeated administration, and this phenomenon is thought to contribute to addiction. The current study examined the effects of drugs of abuse on locomotor activity. Drugs tested were from three major classes: a psychomotor stimulant (methamphetamine, METH), an opiate (oxycodone, OXY), and a dissociative (phencyclidine, PCP). Rats were treated repeatedly during adolescence for 7 days, followed by a second 7-day regimen during adulthood. We hypothesized that animals exposed chronically to drugs as adolescents would show enhanced sensitization as adults. As expected, chronic treatment during adolescence induced locomotor sensitization. However, the follow-up treatment in adulthood yielded mixed results. Although there was evidence of an impact of adolescent treatment for all three drugs, in no case was sensitization greater in adults sensitized as adolescents. For METH and PCP, sensitization in adulthood was reduced in animals previously sensitized as adolescents (relative to animals that were not exposed to drugs as adolescents) whereas for OXY sensitization was not different. These results suggest that exposure to METH, PCP and OXY during adolescence leads to persistent changes, or lack of changes as seen with OXY, in the responses to these drugs in adulthood. These findings have implications for adolescent use of these three major drug classes, and the impact that early drug use may have on adult behavior. Advisors/Committee Members: Trujillo, Keith A (advisor).

Subjects/Keywords: sensitization; adolescence; chronic drug abuse

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Klumph, M. (2013). Impact of Sensitization During Adolescence on Subsequent Drug Response: A Study of Resensitization . (Thesis). California State University – San Marcos. Retrieved from http://hdl.handle.net/10211.8/530

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Klumph, Marianne. “Impact of Sensitization During Adolescence on Subsequent Drug Response: A Study of Resensitization .” 2013. Thesis, California State University – San Marcos. Accessed December 18, 2017. http://hdl.handle.net/10211.8/530.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Klumph, Marianne. “Impact of Sensitization During Adolescence on Subsequent Drug Response: A Study of Resensitization .” 2013. Web. 18 Dec 2017.

Vancouver:

Klumph M. Impact of Sensitization During Adolescence on Subsequent Drug Response: A Study of Resensitization . [Internet] [Thesis]. California State University – San Marcos; 2013. [cited 2017 Dec 18]. Available from: http://hdl.handle.net/10211.8/530.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Klumph M. Impact of Sensitization During Adolescence on Subsequent Drug Response: A Study of Resensitization . [Thesis]. California State University – San Marcos; 2013. Available from: http://hdl.handle.net/10211.8/530

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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