Viscidi, Emma W.
Autism Spectrum Disorder: Comorbidity and Etiology.
Degree: PhD, Epidemiology, 2014, Brown University
Background: Autism Spectrum Disorder (ASD) is a
neurodevelopmental disorder that is estimated to affect as many as
1 in 88 children. Epilepsy is a common comorbid condition in
persons with ASD, but little is known about the prevalence of the
disorder or clinical characteristics of individuals with ASD and
epilepsy. While the cause of ASD is unknown, there is evidence that
prenatal factors may play an etiological role. Objectives: To
examine clinical characteristics of children with ASD and epilepsy
and the association between prenatal risk factors and ASD. Methods:
The association between epilepsy and ASD and prenatal risk factors
for ASD were studied using several large samples. Participants were
drawn from genetic collaborative datasets and population-based
samples, including the Collaborative Perinatal Project (CPP).
Multivariate regression modeling was used to control for
confounding, in particular confounding by cognitive functioning.
Results: Various clinical correlates of ASD and epilepsy were
identified. Low IQ was found to be the best predictor of epilepsy
in children with ASD. Children with epilepsy had more autism
symptoms and maladaptive behaviors than children with ASD alone.
Several prenatal characteristics that increase risk of ASD were
identified including older maternal and paternal age at birth,
bleeding during pregnancy, and edema. Intellectual disability was
found to be a mild confounder of the association between prenatal
risk factors and ASD. Conclusions: In a large sample of children
with ASD, low cognitive ability emerged as a strong independent
predictor of epilepsy. Children with ASD and epilepsy showed
greater impairment than children with ASD without epilepsy, and
this was mostly explained by the lower IQ of children with
epilepsy. Prior associations between prenatal factors and autism
were confirmed in a large population-based cohort study. This study
paves the way for future research on ASD in the Collaborative
Perinatal Project (CPP).
Advisors/Committee Members: Triche, Elizabeth (Director), Buka, Stephen (Reader), Morrow, Eric (Reader), Spence, Sarah (Reader).
Subjects/Keywords: intellectual disability
to Zotero / EndNote / Reference
APA (6th Edition):
Viscidi, E. W. (2014). Autism Spectrum Disorder: Comorbidity and Etiology. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:386141/
Chicago Manual of Style (16th Edition):
Viscidi, Emma W. “Autism Spectrum Disorder: Comorbidity and Etiology.” 2014. Doctoral Dissertation, Brown University. Accessed December 13, 2019.
MLA Handbook (7th Edition):
Viscidi, Emma W. “Autism Spectrum Disorder: Comorbidity and Etiology.” 2014. Web. 13 Dec 2019.
Viscidi EW. Autism Spectrum Disorder: Comorbidity and Etiology. [Internet] [Doctoral dissertation]. Brown University; 2014. [cited 2019 Dec 13].
Available from: https://repository.library.brown.edu/studio/item/bdr:386141/.
Council of Science Editors:
Viscidi EW. Autism Spectrum Disorder: Comorbidity and Etiology. [Doctoral Dissertation]. Brown University; 2014. Available from: https://repository.library.brown.edu/studio/item/bdr:386141/