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1.
Warschun, Briana Michele.
Changes in Bone Morphology with Carpometacarpal
Osteoarthritis.
Degree: Biomedical Engineering, 2017, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:733557/ 
► Characterizing the morphology of the carpometacarpal (CMC) joint and how it changes with osteoarthritis progression is important for understanding the pathoetiology of this multifactorial disease.…
(more)
▼ Characterizing the morphology of the carpometacarpal
(CMC) joint and how it changes with osteoarthritis progression is
important for understanding the pathoetiology of this
multifactorial disease. The purpose of this longitudinal in vivo
study was to quantitatively describe shape and morphology changes
associated with OA progression from enrollment to 3.0 yr follow-up
and to determine if and how these changes may differ with sex.
Computed tomography scans from 74 subjects with early CMC OA and 24
healthy (control) age-matched subjects were used to obtain 3-D bone
models. The trapezial and metacarpal articular surfaces were
manually described and compared among sex and health groups using a
scalar measure of average differences across facet surface shape as
well as a novel scalar measure of the relative position of the
facet surface with respect to bone inertia to describe facet
orientation. We found that with OA progression bone volume will
increase and CMC articulation becomes more curved in the
dorsal-volar direction in both men and women. These findings
support a modest effect of OA progression on the shape and
morphology of the CMC articulation and these changes are likely to
continue to increase over time as OA progresses. Likewise, we found
sex-related differences among the trapezia facet orientation, which
may play a factor in the higher CMC OA prevalence in women than in
men.
Advisors/Committee Members: Schell, Jacquelyn (Reader), Franck, Christian (Reader), Crisco, Joseph J. (Advisor).
Subjects/Keywords: Biomechanics
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APA (6th Edition):
Warschun, B. M. (2017). Changes in Bone Morphology with Carpometacarpal
Osteoarthritis. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:733557/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Warschun, Briana Michele. “Changes in Bone Morphology with Carpometacarpal
Osteoarthritis.” 2017. Thesis, Brown University. Accessed April 20, 2021.
https://repository.library.brown.edu/studio/item/bdr:733557/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Warschun, Briana Michele. “Changes in Bone Morphology with Carpometacarpal
Osteoarthritis.” 2017. Web. 20 Apr 2021.
Vancouver:
Warschun BM. Changes in Bone Morphology with Carpometacarpal
Osteoarthritis. [Internet] [Thesis]. Brown University; 2017. [cited 2021 Apr 20].
Available from: https://repository.library.brown.edu/studio/item/bdr:733557/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Warschun BM. Changes in Bone Morphology with Carpometacarpal
Osteoarthritis. [Thesis]. Brown University; 2017. Available from: https://repository.library.brown.edu/studio/item/bdr:733557/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
2.
Alois, Jaclyn.
Play Mechanisms Associated With Intentional High-Magnitude
Impacts In Youth Football.
Degree: Department of Molecular Pharmacology, Physiology and
Biotechnology, 2018, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:792750/
► Creating the safest possible playing environment for football athletes has been at the forefront of researchers and governing bodies alike. While most of the research…
(more)
▼ Creating the safest possible playing environment for
football athletes has been at the forefront of researchers and
governing bodies alike. While most of the research has focused
primarily on high school and collegiate football players, this
study aimed to identify the circumstances of which high-risk
impacts occur in the youth population ages 8 to 14. This study
specifically investigated the mechanism associated with intentional
high-magnitude impacts by comparing the impact mechanism
distribution across session type, player position, and ball
possession. Sixty-eight players from four youth teams were
recruited and equipped with the Head Impact Telemetry (HIT) System
enabling magnitude and frequency of head impact exposures to be
collected during 119 practices and 34 games. Over one season of
play, 1,071 of the 1,319 of the high-magnitude impacts processed
from video footage were intentional. The Head-to-Head mechanism was
the primary impact mechanism (n=868, 82.7%) of the 1,050
intentional high-magnitude impacts whose mechanism could be
determined, followed by Head-to-Body (n=139, 13.2%), Head-to-Ground
(n=34, 3.2%), and Head-to-Equipment (n=9, 0.9%). Head-to-Head
impacts accounted for a greater proportion of impacts in practice
(n=625, 88.9%) than games, for Line players (n=585, 90.3%) than
Perimeters and Backs, and for Ball Carriers (n=72, 81.8%) than
Tacklers. Overall, the majority of high-magnitude impacts were
intentional and resulted from Head-to-Head contact. The proportion
of Head-to-Head contact was significantly higher in practice, for
Line players, and for Ball Carriers. Video analysis for impact
mechanisms and characterization according to various categorical
variables is critical in developing future prevention
strategies
Advisors/Committee Members: Crisco, Joseph (Advisor), Franck, Christian (Reader), Achilli, Toni-Marie (Reader).
Subjects/Keywords: Youth league football
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Manager
APA (6th Edition):
Alois, J. (2018). Play Mechanisms Associated With Intentional High-Magnitude
Impacts In Youth Football. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:792750/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Alois, Jaclyn. “Play Mechanisms Associated With Intentional High-Magnitude
Impacts In Youth Football.” 2018. Thesis, Brown University. Accessed April 20, 2021.
https://repository.library.brown.edu/studio/item/bdr:792750/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Alois, Jaclyn. “Play Mechanisms Associated With Intentional High-Magnitude
Impacts In Youth Football.” 2018. Web. 20 Apr 2021.
Vancouver:
Alois J. Play Mechanisms Associated With Intentional High-Magnitude
Impacts In Youth Football. [Internet] [Thesis]. Brown University; 2018. [cited 2021 Apr 20].
Available from: https://repository.library.brown.edu/studio/item/bdr:792750/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Alois J. Play Mechanisms Associated With Intentional High-Magnitude
Impacts In Youth Football. [Thesis]. Brown University; 2018. Available from: https://repository.library.brown.edu/studio/item/bdr:792750/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
3.
Halilaj, Eni.
Image-Based Analysis of Thumb Carpometacarpal Joint
Biomechanics in Health and Early Osteoarthritis.
Degree: PhD, Biomedical Engineering, 2015, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:419393/
► Humans have a unique opposable thumb that maintains a fine balance between mobility and stability to allow motions that span from precision handling to power…
(more)
▼ Humans have a unique opposable thumb that maintains a
fine balance between mobility and stability to allow motions that
span from precision handling to power grasping. Much of the
versatility of the thumb is due to the saddle geometry of first
carpometacarpal (CMC) joint. Located at the base of the thumb, the
CMC joint is the most common site of reconstructive surgery in the
upper extremity. Nearly 40% of postmenopausal women are affected by
CMC osteoarthritis (OA)—a progressive degenerative disease of
articular cartilage, bone, and synovium that results in decreased
dexterity and partial impairment of the upper extremity. Although
current treatment options can alleviate pain, they cannot restore
the lost strength and mobility, or halt disease progression,
because the pathophysiology of the disease is poorly understood.
While both biological and mechanical factors are implicated in the
etiology of CMC OA, the synergistic mechanism of disease evolution
remains unclear, partially due to a paucity of published data on
CMC joint biomechanics in healthy and diseased populations.
Accordingly, the objective of this work was to study CMC joint
biomechanics using in vivo image-based techniques, and to determine
if there are any differences with sex, age, or OA onset that could
point to the etiology of the disease. 155 subjects—healthy men and
women of two age groups and patients with early stage CMC OA—were
recruited for the study. Sequential computed tomography scans of
the hands and wrists of all the participants were acquired while
they performed functional tasks and range-of-motion activities. The
imaging data were used to study joint motion, stability, contact
mechanics, articular shape and congruence, as well as to model soft
tissue: cartilage and ligaments. The findings presented here
suggest that there may not be a mechanical predisposition to CMC
OA, but that women may be more susceptible to cartilage loss due to
systemic changes with aging. In addition to channeling future
research in the right direction, the furthered understanding of CMC
joint biomechanics should serve to refine the current surgical
procedures and to inspire new conservative options for disease
treatment and prevention.
Advisors/Committee Members: Crisco, Joseph (Director), Laidlaw, David (Director), Sharon, Swartz (Reader), Braden, Flemming (Reader), Amy, Ladd (Reader).
Subjects/Keywords: in vivo joint kinematics
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Manager
APA (6th Edition):
Halilaj, E. (2015). Image-Based Analysis of Thumb Carpometacarpal Joint
Biomechanics in Health and Early Osteoarthritis. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:419393/
Chicago Manual of Style (16th Edition):
Halilaj, Eni. “Image-Based Analysis of Thumb Carpometacarpal Joint
Biomechanics in Health and Early Osteoarthritis.” 2015. Doctoral Dissertation, Brown University. Accessed April 20, 2021.
https://repository.library.brown.edu/studio/item/bdr:419393/.
MLA Handbook (7th Edition):
Halilaj, Eni. “Image-Based Analysis of Thumb Carpometacarpal Joint
Biomechanics in Health and Early Osteoarthritis.” 2015. Web. 20 Apr 2021.
Vancouver:
Halilaj E. Image-Based Analysis of Thumb Carpometacarpal Joint
Biomechanics in Health and Early Osteoarthritis. [Internet] [Doctoral dissertation]. Brown University; 2015. [cited 2021 Apr 20].
Available from: https://repository.library.brown.edu/studio/item/bdr:419393/.
Council of Science Editors:
Halilaj E. Image-Based Analysis of Thumb Carpometacarpal Joint
Biomechanics in Health and Early Osteoarthritis. [Doctoral Dissertation]. Brown University; 2015. Available from: https://repository.library.brown.edu/studio/item/bdr:419393/
4.
Waller, Kimberly A.
Preventing Biological Wear in the Synovial Joint: The Role
of Lubricin as a Boundary Lubricant and Tribosupplement.
Degree: PhD, Biomedical Engineering, 2013, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:320658/
► Articular cartilage is a smooth, load bearing tissue that lines the ends of bones in articulating joints. Smooth joint motion is facilitated by synovial fluid,…
(more)
▼ Articular cartilage is a smooth, load bearing tissue
that lines the ends of bones in articulating joints. Smooth joint
motion is facilitated by synovial fluid, which contains the
lubricating factors lubricin and hyaluronic acid. While healthy
articular cartilage can sustain decades of use, a variety of common
risk factors, including age, obesity and injury, predispose many
patients to degenerative joint diseases, including osteoarthritis
(OA), which is characterized by joint pain, loss of motion and
cartilage loss. Although OA is a widespread disease, treatment
options are limited to pain management and total joint replacement.
Lubricin is a mucinous glycoprotein produced by synovial
cells and chondrocytes that forms a layer of molecules over the
surface of healthy cartilage, providing boundary lubrication and
chondroprotection to articulating joints. In its absence, articular
cartilage experiences elevated friction and subsequent mechanical
and biological damage.
This work investigates the efficacy of lubricin to prevent
both mechanical and biological wear of articular cartilage, using
in vitro, in vivo and ex vivo models. We developed an in vitro
cartilage lubrication and wear testing regimen that allows for
subsequent cell culture and observation of the cellular response to
friction and wear, which facilitates the testing of lubricants and
therapeutics to evaluate OA treatments and prevention, and can be
used to study different cartilaginous bearings in order to observe
the lubrication and wear response in compromised tissues. In
addition, we used animal models to investigate exogenous and
endogenous tribosupplementation of lubricin, which provide insight
into the treatment of degenerative joint diseases.
In this dissertation, we show that lubricin is vital to
boundary lubrication and the preservation of joint health at both
the structural and cellular levels. Furthermore, we show that
tribosupplementation provides joint lubrication and prevents
apoptosis of chondrocytes in lubricin deficient disease models.
The major findings in this dissertation support further
investigation of lubricin as a tribosupplenent in large animal
preclinical models and in patients with genetic or acquired
lubricin deficiency, who have unmet medical needs. Furthermore,
this work provides insight into the mechanopathway relating
friction and apoptosis, which provides groundwork for additional
therapeutic targets in the prevention of biological
wear.
Advisors/Committee Members: Jay, Gregory (Director), Crisco, Joseph (Reader), Darling, Eric (Reader), Fleming, Braden (Reader), Elsaid, Khaled (Reader).
Subjects/Keywords: lubricin
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Manager
APA (6th Edition):
Waller, K. A. (2013). Preventing Biological Wear in the Synovial Joint: The Role
of Lubricin as a Boundary Lubricant and Tribosupplement. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:320658/
Chicago Manual of Style (16th Edition):
Waller, Kimberly A. “Preventing Biological Wear in the Synovial Joint: The Role
of Lubricin as a Boundary Lubricant and Tribosupplement.” 2013. Doctoral Dissertation, Brown University. Accessed April 20, 2021.
https://repository.library.brown.edu/studio/item/bdr:320658/.
MLA Handbook (7th Edition):
Waller, Kimberly A. “Preventing Biological Wear in the Synovial Joint: The Role
of Lubricin as a Boundary Lubricant and Tribosupplement.” 2013. Web. 20 Apr 2021.
Vancouver:
Waller KA. Preventing Biological Wear in the Synovial Joint: The Role
of Lubricin as a Boundary Lubricant and Tribosupplement. [Internet] [Doctoral dissertation]. Brown University; 2013. [cited 2021 Apr 20].
Available from: https://repository.library.brown.edu/studio/item/bdr:320658/.
Council of Science Editors:
Waller KA. Preventing Biological Wear in the Synovial Joint: The Role
of Lubricin as a Boundary Lubricant and Tribosupplement. [Doctoral Dissertation]. Brown University; 2013. Available from: https://repository.library.brown.edu/studio/item/bdr:320658/
5.
Rainbow, Michael John.
An Examination of Carpal Joint Function using Kinematic
Analysis and Predictive Modeling.
Degree: PhD, Biomedical Engineering, 2012, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:297579/
► As a versatile joint, the wrist remains stable through large motions under a variety of loading conditions. Wrist motion is achieved through the individual articulations…
(more)
▼ As a versatile joint, the wrist remains stable through
large motions under a variety of loading conditions. Wrist motion
is achieved through the individual articulations of eight small
carpal bones situated distal to the radius and ulna and proximal to
the metacarpals. With minimal direct muscular attachments, the
carpus is a passive joint. From an engineering perspective, it can
be modeled as a mechanical linkage composed of multiple rigid
bodies and a system of elastic elements. The carpal bones transmit
force through tensile strain in the ligaments and through
compressive strain in the articular cartilage. These forces
facilitate the positioning of the metacarpals with respect to the
forearm; the direct measurement of these cartilage and ligament
forces would fully elucidate the function of the joint. However,
the carpus is part of a living biological system and assembling a
mechanical model is associated with a unique set of challenges. The
aim of this dissertation is to extend our understanding of carpal
joint function with special emphasis on the carpal ligaments. The
following Chapter provides background information on the carpus,
focusing on functional anatomy, a brief history and discussion of
related research, and specifc aims designed to address unanswered
questions about the function of the carpal joint.
Advisors/Committee Members: Crisco, Joseph (Director), Buczek, Frank (Reader), Fleming, Braden (Reader), Laidlaw, David (Reader), Roberts, Thomas (Reader).
Subjects/Keywords: Computed Tomgraphy
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Manager
APA (6th Edition):
Rainbow, M. J. (2012). An Examination of Carpal Joint Function using Kinematic
Analysis and Predictive Modeling. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:297579/
Chicago Manual of Style (16th Edition):
Rainbow, Michael John. “An Examination of Carpal Joint Function using Kinematic
Analysis and Predictive Modeling.” 2012. Doctoral Dissertation, Brown University. Accessed April 20, 2021.
https://repository.library.brown.edu/studio/item/bdr:297579/.
MLA Handbook (7th Edition):
Rainbow, Michael John. “An Examination of Carpal Joint Function using Kinematic
Analysis and Predictive Modeling.” 2012. Web. 20 Apr 2021.
Vancouver:
Rainbow MJ. An Examination of Carpal Joint Function using Kinematic
Analysis and Predictive Modeling. [Internet] [Doctoral dissertation]. Brown University; 2012. [cited 2021 Apr 20].
Available from: https://repository.library.brown.edu/studio/item/bdr:297579/.
Council of Science Editors:
Rainbow MJ. An Examination of Carpal Joint Function using Kinematic
Analysis and Predictive Modeling. [Doctoral Dissertation]. Brown University; 2012. Available from: https://repository.library.brown.edu/studio/item/bdr:297579/
6.
Biercevicz, Alison M.
A Translational Method to Quantify Anterior Cruciate
Ligament Healing Using Magnetic Resonance Imaging for Research and
Clinical Applications.
Degree: PhD, Biomedical Engineering, 2015, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:419431/
► The goal of this thesis was to use non-invasive quantifiable MR parameters of volume, signal intensity and T2* relaxation time to predict the biomechanical or…
(more)
▼ The goal of this thesis was to use non-invasive
quantifiable MR parameters of volume, signal intensity and T2*
relaxation time to predict the biomechanical or histological
outcomes of an ACL graft or ACL repair as a surrogate outcome
measure for healing. The main focus of this thesis was on
developing imaging methods for determining these MR parameters and
evaluating how these parameters could be used to assess ligament or
graft healing, in both animal models and in clinical trials. Our
first goal was to design an MR imaging method to predict the
structural properties of a healing ligament or graft in a large
animal model. We found that the linear combination of MR derived
volume and SI, as a surrogate for tissue integrity, predicted ex
vivo structural properties in a healing ACL or graft. As a further
refinement of this approach, it was found partial volumes defined
by equal intervals of T2*, predicted structural properties of a
healing ligament with the benefit of T2* being an inherent tissue
property with potential to be standardized across institutions. In
addition to being predictive of gross biomechanical performance,
T2* was also found to be predictive of histological outcomes that
have been associated with ligament healing on a microscopic level.
A complimentary study determined that these same imaging parameters
were not significantly associated with biomechanical performance of
degenerating ACLs in a human cadaveric population clustered around
50 years of age. Inherent differences with the macro or micro
anatomy of the degenerating ligaments may have lead to the
insignificant findings. Finally, as a translational step, the
combination of volume and SI were found to be predictive of
traditional outcomes, such as, the hop test, for patients that
received ACL reconstruction. The noninvasive MR methods presented
here for predicting the structural properties and histological
outcomes of the graft or ligament will allow researchers to
document healing longitudinally within a specimen in pre-clinical
animal studies. Furthermore, these findings may have implications
as a surrogate outcome measure in clinical studies for documenting
temporal changes within-patients and as a more quantitative method
for guiding rehabilitation.
Advisors/Committee Members: Fleming, Braden (Director), Crisco, Joseph (Reader), Darling, Eric (Reader), Deoni, Sean (Reader), Thornton, Gail (Reader).
Subjects/Keywords: Orthopaedics
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APA ·
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Manager
APA (6th Edition):
Biercevicz, A. M. (2015). A Translational Method to Quantify Anterior Cruciate
Ligament Healing Using Magnetic Resonance Imaging for Research and
Clinical Applications. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:419431/
Chicago Manual of Style (16th Edition):
Biercevicz, Alison M. “A Translational Method to Quantify Anterior Cruciate
Ligament Healing Using Magnetic Resonance Imaging for Research and
Clinical Applications.” 2015. Doctoral Dissertation, Brown University. Accessed April 20, 2021.
https://repository.library.brown.edu/studio/item/bdr:419431/.
MLA Handbook (7th Edition):
Biercevicz, Alison M. “A Translational Method to Quantify Anterior Cruciate
Ligament Healing Using Magnetic Resonance Imaging for Research and
Clinical Applications.” 2015. Web. 20 Apr 2021.
Vancouver:
Biercevicz AM. A Translational Method to Quantify Anterior Cruciate
Ligament Healing Using Magnetic Resonance Imaging for Research and
Clinical Applications. [Internet] [Doctoral dissertation]. Brown University; 2015. [cited 2021 Apr 20].
Available from: https://repository.library.brown.edu/studio/item/bdr:419431/.
Council of Science Editors:
Biercevicz AM. A Translational Method to Quantify Anterior Cruciate
Ligament Healing Using Magnetic Resonance Imaging for Research and
Clinical Applications. [Doctoral Dissertation]. Brown University; 2015. Available from: https://repository.library.brown.edu/studio/item/bdr:419431/
7.
Wilcox, Bethany J.
Head Impact Exposure: The Biomechanics of Sports-Related
Concussions.
Degree: PhD, Biomedical Engineering, 2014, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:386172/
► In our approach to understanding the biomechanics of concussions, we have defined head impact exposure as a multifactorial term that includes the frequency, magnitude, and…
(more)
▼ In our approach to understanding the biomechanics of
concussions, we have defined head impact exposure as a
multifactorial term that includes the frequency, magnitude, and
impact location of head impacts for individual athletes. The
primary objectives of this dissertation were to collect and
quantify head impact exposure in several populations of contact
sport athletes, examine these variables in relation to head impact
mechanisms, correlate this data with clinical outcomes related to
concussion, and assess the differences between males and females in
these measures. We found that head impact exposure for individual
athletes is sport and gender-specific, and dependent upon team,
session type, and player position. We also found head impact
exposure is correlated with diagnosed concussions. Based on these
findings, we have proposed that reducing an individual’s head
impact exposure is a practical approach for reducing the risk of
brain injuries. To investigate strategies for reducing head impact
exposure, we synchronized impact data with game video footage to
evaluate the biomechanics of head impacts associated with specific
head impact mechanisms (e.g. head contact with the ice in hockey)
to determine which circumstances of play result in frequent or high
magnitude head impacts. Finally, we evaluated differences between
males and females in concussion rate and the biomechanics of head
impacts associated with diagnosed concussion. Female hockey players
had significantly higher rates of concussion per head impact than
male football players. While females had higher rates of
concussions than males, single impacts associated with concussion
and head impact exposure on days of diagnosed concussions were
lower for female hockey players compared to male football players.
These findings suggest that females may have a lower biomechanical
tolerance to concussion injuries. Only fifty percent of the
concussions that were diagnosed during the course of the study were
associated with a single impact, indicating there may be a
cumulative effect of head impacts. The outcomes of this study allow
for the development and validation of improved on-field concussion
management (including early detection and accurate diagnosis),
prevention strategies, and interventions. Additionally, data from
this study may inform and improve future helmet
design.
Advisors/Committee Members: Crisco, Joseph (Director), Fleming, Braden (Reader), Franck, Christian (Reader), Raukar, Neha (Reader), Greenwald, Richard (Reader).
Subjects/Keywords: concussion
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MLA ·
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Export
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Manager
APA (6th Edition):
Wilcox, B. J. (2014). Head Impact Exposure: The Biomechanics of Sports-Related
Concussions. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:386172/
Chicago Manual of Style (16th Edition):
Wilcox, Bethany J. “Head Impact Exposure: The Biomechanics of Sports-Related
Concussions.” 2014. Doctoral Dissertation, Brown University. Accessed April 20, 2021.
https://repository.library.brown.edu/studio/item/bdr:386172/.
MLA Handbook (7th Edition):
Wilcox, Bethany J. “Head Impact Exposure: The Biomechanics of Sports-Related
Concussions.” 2014. Web. 20 Apr 2021.
Vancouver:
Wilcox BJ. Head Impact Exposure: The Biomechanics of Sports-Related
Concussions. [Internet] [Doctoral dissertation]. Brown University; 2014. [cited 2021 Apr 20].
Available from: https://repository.library.brown.edu/studio/item/bdr:386172/.
Council of Science Editors:
Wilcox BJ. Head Impact Exposure: The Biomechanics of Sports-Related
Concussions. [Doctoral Dissertation]. Brown University; 2014. Available from: https://repository.library.brown.edu/studio/item/bdr:386172/
8.
Drewniak, Elizabeth I.
Tribological Properties of Lubricin Mutant Mouse Knee
Joints.
Degree: PhD, Biomedical Engineering, 2011, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:11217/
► Tribology is the study of friction, wear, and lubrication. For the past several decades, the engineering principles of tribology have been used in attempts to…
(more)
▼ Tribology is the study of friction, wear, and
lubrication. For the past several decades, the engineering
principles of tribology have been used in attempts to better
understand articular cartilage (AC), the connective tissue that
lines the ends of bones within synovial joints. In addition to
providing relative motion while minimizing fiction and wear, AC
disperses loads throughout the joint. By distributing loads, AC
decreases the stresses experienced within joint tissues. While
healthy AC allows for decades of painless motion, many Americans
will eventually develop osteoarthritis (OA), a degenerative joint
disease characterized by pain and progressive loss of AC. Lubricin,
a joint lubricating factor encoded by the Prg4 gene, provides
chondroprotection by acting as a boundary lubricant, a cell
adhesion inhibitor, and a synoviocyte growth regulator; hence,
potentially protecting AC from OA.The long-term goal of this line
of research would ultimately be the development of a tribological
supplement for synovial joints at-risk for the onset and
development of OA. However, the work presented within this
dissertation serves to address the more immediate goal of
developing a whole joint testing system capable of investigating
the tribological properties of lubricin mutant mouse knee joints.
This goal was accomplished using two pendulum systems designed to
provide ex vivo biomechanical testing of intact mouse knee joints.
The work presented within this dissertation established methods for
assessing the effects of cyclic loading on the bulk frictional
properties and cartilage surface integrity of lubricin mutant mouse
knee joints. These findings support and complement the existing
data pertaining to the vital role that lubricin plays within
synovial joints. These results also demonstrate that long-term
whole joint tribological testing is possible and should be pursued
further. Additionally, this work revealed a lubricin-dosing
response within Prg4 mouse joints, which could have clinically
relevant implications for carriers of CACP: lack of a functional
Prg4 allele may place these individuals at a potentially greater
risk for developing OA, or other synovial joint disorders. Lastly,
the pendulum systems developed for this research will allow for
future long-term ex vivo biomechanical studies of intact knee
joints.
Advisors/Committee Members: Crisco, Joseph (Director), Jay, Gregory (Reader), Fleming, Braden (Reader), Darling, Eric (Reader), Guilak, Farshid (Reader).
Subjects/Keywords: coefficient of friction
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APA (6th Edition):
Drewniak, E. I. (2011). Tribological Properties of Lubricin Mutant Mouse Knee
Joints. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:11217/
Chicago Manual of Style (16th Edition):
Drewniak, Elizabeth I. “Tribological Properties of Lubricin Mutant Mouse Knee
Joints.” 2011. Doctoral Dissertation, Brown University. Accessed April 20, 2021.
https://repository.library.brown.edu/studio/item/bdr:11217/.
MLA Handbook (7th Edition):
Drewniak, Elizabeth I. “Tribological Properties of Lubricin Mutant Mouse Knee
Joints.” 2011. Web. 20 Apr 2021.
Vancouver:
Drewniak EI. Tribological Properties of Lubricin Mutant Mouse Knee
Joints. [Internet] [Doctoral dissertation]. Brown University; 2011. [cited 2021 Apr 20].
Available from: https://repository.library.brown.edu/studio/item/bdr:11217/.
Council of Science Editors:
Drewniak EI. Tribological Properties of Lubricin Mutant Mouse Knee
Joints. [Doctoral Dissertation]. Brown University; 2011. Available from: https://repository.library.brown.edu/studio/item/bdr:11217/
9.
Bowers, Megan E.
Partial Meniscectomy and Osteoarthritis: Evaluation with
Quantitative Magnetic Resonance Imaging.
Degree: PhD, Biomedical Engineering, 2010, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:11076/
► Menisci are essential for long-term knee joint function. Injuries to the menisci are common. Meniscal tears are often treated with arthroscopic partial meniscectomy (PM), a…
(more)
▼ Menisci are essential for long-term knee joint
function. Injuries to the menisci are common. Meniscal tears are
often treated with arthroscopic partial meniscectomy (PM), a common
procedure in which the torn area of the meniscus is removed, while
the unaffected, stable portion is left intact. A meniscal tear and
its surgical treatment may place the knee at risk of developing
osteoarthritis (OA) because it may disrupt the load-bearing and
protective functions of the meniscus. In the case of a symptomatic
meniscal tear, partial resection is routinely performed to
eliminate symptoms while attempting to preserve the integrity of
the articular cartilage. It is unknown, however, whether there is a
critical amount of meniscal tissue that can be removed without
diminishing the structure's chondroprotective function. The
long-term objective of this work is to identify whether such a
threshold exists by measuring the volume of meniscal tissue removed
during PM and tracking OA development using quantitative magnetic
resonance imaging (MRI) to assess articular cartilage thickness. In
order to examine the existence of such a threshold, it is necessary
to first develop non-invasive techniques to examine meniscal
morphometry and articular cartilage thickness in vivo. The
immediate goals of this work, therefore, were to refine, validate,
and apply MR imaging-based methods for quantifying meniscal volume,
and for mapping and quantifying changes in articular cartilage
thickness within the tibiofemoral joint. The studies described
within this dissertation provide the groundwork necessary to
develop and justify a long-term prospective controlled cohort study
evaluating OA following meniscal injury and PM. Such a study will
influence the future care of patients undergoing surgical treatment
for meniscus changes. This will be particularly important when a
patient and his or her clinician choose between PM and other more
complicated, expensive treatment alternatives, which may include
repair, allografts, xenografts, and tissue-engineered replacements.
Data from a long-term prospective study will also provide a glimpse
into the changes in articular cartilage thickness that occur after
injury and its surgical treatment, and may allow researchers to
elucidate the mechanisms involved in post-traumatic OA
development.
Advisors/Committee Members: Fleming, Braden (Director), Crisco, Joseph (Reader), Tung, Glenn (Reader), Kimia, Benjamin (Reader), Murray, Martha (Reader).
Subjects/Keywords: imaging
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MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bowers, M. E. (2010). Partial Meniscectomy and Osteoarthritis: Evaluation with
Quantitative Magnetic Resonance Imaging. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:11076/
Chicago Manual of Style (16th Edition):
Bowers, Megan E. “Partial Meniscectomy and Osteoarthritis: Evaluation with
Quantitative Magnetic Resonance Imaging.” 2010. Doctoral Dissertation, Brown University. Accessed April 20, 2021.
https://repository.library.brown.edu/studio/item/bdr:11076/.
MLA Handbook (7th Edition):
Bowers, Megan E. “Partial Meniscectomy and Osteoarthritis: Evaluation with
Quantitative Magnetic Resonance Imaging.” 2010. Web. 20 Apr 2021.
Vancouver:
Bowers ME. Partial Meniscectomy and Osteoarthritis: Evaluation with
Quantitative Magnetic Resonance Imaging. [Internet] [Doctoral dissertation]. Brown University; 2010. [cited 2021 Apr 20].
Available from: https://repository.library.brown.edu/studio/item/bdr:11076/.
Council of Science Editors:
Bowers ME. Partial Meniscectomy and Osteoarthritis: Evaluation with
Quantitative Magnetic Resonance Imaging. [Doctoral Dissertation]. Brown University; 2010. Available from: https://repository.library.brown.edu/studio/item/bdr:11076/
10.
Bellamkonda, Srinidhi.
Head Impact Exposure in Youth Football Players at Practices
and Games.
Degree: Biomedical Engineering, 2017, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:733270/
► Despite over 70% of all football players in the US being under the age of 14, previous research has focused primarily on high school and…
(more)
▼ Despite over 70% of all football players in the US
being under the age of 14, previous research has focused primarily
on high school and collegiate football players. With the goal of
learning more about the distribution of head impact exposure in the
youth population, this study aimed to compare head impact exposure
data (frequency and magnitude) between practices and games on
football players ages 9 to 14. One hundred thirty-six players from
six teams were recruited and equipped with the HIT (Head Impact
Telemetry) system enabling impact exposure data collection at every
practice and game for a total of 482 sessions. Over a period of two
seasons, 49,847 impacts from 345 practices and 137 games were
recorded. Individual players sustained a median of 211 impacts with
a highest of 1226 impacts per season, with a 50th and 95th
percentile peak linear acceleration of 18.3 g and 46.9 g. The 50th
and 95th percentile peak rotational acceleration were 1305.4 rad/s2
and 3316.6 rad/s2 respectively and the 50th and 95th peak
percentile HITsp, a severity measure, were 13.7 and 24.3,
respectively. Overall, players with a higher frequency of head
impacts at practice recorded a higher frequency of head impacts at
games. While there were differences in total number of head impacts
an individual player received per season among each of the six
teams, there was a positive correlation between the head impact
frequencies players sustained at practices and at games. Moreover,
players with higher magnitudes of head impacts during practice also
recorded higher magnitudes of head impacts during games.
Essentially, for every individual player, there was a positive
significant linear relationship between the head impact exposure
values for games and for practices.
Advisors/Committee Members: Horrigan, Diana M. (Reader), Burke, Brian C. (Reader), Crisco, Joseph J.(Trey) (Advisor).
Subjects/Keywords: Head Injury
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bellamkonda, S. (2017). Head Impact Exposure in Youth Football Players at Practices
and Games. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:733270/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Bellamkonda, Srinidhi. “Head Impact Exposure in Youth Football Players at Practices
and Games.” 2017. Thesis, Brown University. Accessed April 20, 2021.
https://repository.library.brown.edu/studio/item/bdr:733270/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Bellamkonda, Srinidhi. “Head Impact Exposure in Youth Football Players at Practices
and Games.” 2017. Web. 20 Apr 2021.
Vancouver:
Bellamkonda S. Head Impact Exposure in Youth Football Players at Practices
and Games. [Internet] [Thesis]. Brown University; 2017. [cited 2021 Apr 20].
Available from: https://repository.library.brown.edu/studio/item/bdr:733270/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Bellamkonda S. Head Impact Exposure in Youth Football Players at Practices
and Games. [Thesis]. Brown University; 2017. Available from: https://repository.library.brown.edu/studio/item/bdr:733270/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
11.
Leventhal, Evan L.
Carpal Kinematics During Functional Tasks: A 3-D In Vivo
Analysis of Simulated Hammering and Carpal Distraction.
Degree: PhD, Biomedical Engineering, 2010, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:11065/
► The wrist is perhaps the most complex joint in the human body and serves as the critical biomechanical link between the forearm and the hand.…
(more)
▼ The wrist is perhaps the most complex joint in the
human body and serves as the critical biomechanical link between
the forearm and the hand. Historically, our understanding of carpal
kinematics has been limited by studies using inaccurate surface
measurements or using invasive markers which can alter bone motion.
Only with the recent development of markerless bone registration
technology have we been able to accurately and noninvasively
measure in vivo carpal kinematics. Using this new technology,
researchers have mainly focused on measuring carpal kinematics
during normal range-of-motion movements and low-demand tasks. There
remains a paucity of data on the kinematics of the eight carpal
bones during functional tasks and under load. There were two
primary goals of this work: (1) to measure the in vivo
three-dimensional kinematics of the wrist and forearm during
simulated hammering, a dominant task of modern man and an important
functional motion; and (2) to measure the in vivo effect of a
tensile distractive load on the conformation of the carpus. Using
computed tomography, the dominant wrists of 14 healthy volunteers
were scanned at five positions in a simulated hammering task. These
same volunteers were also scanned at rest and during application of
98 N of distraction using finger traps. The motions of the bones in
the distal forearm, carpal bones, and metacarpals were tracked
using markerless bone registration. The resulting kinematic data
showed that the path of wrist motion during simulated hammering
follows a dart throwing motion, although the hammering path is
offset in wrist extension compared to the most commonly studied
dart throwing motion. During simulated hammering, scaphoid and
lunate rotation were reduced and the magnitude of this rotation was
dependent upon the orientation of the hammering path. After carpal
distraction, separation at the lunocapitate joint was greater than
at the radiolunate joint, and there was no significant separation
at the carpal-metacarpal joint.
Advisors/Committee Members: Crisco, Joseph (Director), Akelman, Edward (Reader), Flemin, Braden (Reader), Laidlaw, David (Reader), Wolfe, Scott (Reader).
Subjects/Keywords: scaphoid
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Leventhal, E. L. (2010). Carpal Kinematics During Functional Tasks: A 3-D In Vivo
Analysis of Simulated Hammering and Carpal Distraction. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:11065/
Chicago Manual of Style (16th Edition):
Leventhal, Evan L. “Carpal Kinematics During Functional Tasks: A 3-D In Vivo
Analysis of Simulated Hammering and Carpal Distraction.” 2010. Doctoral Dissertation, Brown University. Accessed April 20, 2021.
https://repository.library.brown.edu/studio/item/bdr:11065/.
MLA Handbook (7th Edition):
Leventhal, Evan L. “Carpal Kinematics During Functional Tasks: A 3-D In Vivo
Analysis of Simulated Hammering and Carpal Distraction.” 2010. Web. 20 Apr 2021.
Vancouver:
Leventhal EL. Carpal Kinematics During Functional Tasks: A 3-D In Vivo
Analysis of Simulated Hammering and Carpal Distraction. [Internet] [Doctoral dissertation]. Brown University; 2010. [cited 2021 Apr 20].
Available from: https://repository.library.brown.edu/studio/item/bdr:11065/.
Council of Science Editors:
Leventhal EL. Carpal Kinematics During Functional Tasks: A 3-D In Vivo
Analysis of Simulated Hammering and Carpal Distraction. [Doctoral Dissertation]. Brown University; 2010. Available from: https://repository.library.brown.edu/studio/item/bdr:11065/
12.
Waller, Kimberly A.
Preventing Biological Wear in the Synovial Joint: The Role
of Lubricin as a Boundary Lubricant and Tribosupplement.
Degree: PhD, Biomedical Engineering, 2013, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:320659/
► Articular cartilage is a smooth, load bearing tissue that lines the ends of bones in articulating joints. Smooth joint motion is facilitated by synovial fluid,…
(more)
▼ Articular cartilage is a smooth, load bearing tissue
that lines the ends of bones in articulating joints. Smooth joint
motion is facilitated by synovial fluid, which contains the
lubricating factors lubricin and hyaluronic acid. While healthy
articular cartilage can sustain decades of use, a variety of common
risk factors, including age, obesity and injury, predispose many
patients to degenerative joint diseases, including osteoarthritis
(OA), which is characterized by joint pain, loss of motion and
cartilage loss. Although OA is a widespread disease, treatment
options are limited to pain management and total joint replacement.
Lubricin is a mucinous glycoprotein produced by synovial
cells and chondrocytes that forms a layer of molecules over the
surface of healthy cartilage, providing boundary lubrication and
chondroprotection to articulating joints. In its absence, articular
cartilage experiences elevated friction and subsequent mechanical
and biological damage.
This work investigates the efficacy of lubricin to prevent
both mechanical and biological wear of articular cartilage, using
in vitro, in vivo and ex vivo models. We developed an in vitro
cartilage lubrication and wear testing regimen that allows for
subsequent cell culture and observation of the cellular response to
friction and wear, which facilitates the testing of lubricants and
therapeutics to evaluate OA treatments and prevention, and can be
used to study different cartilaginous bearings in order to observe
the lubrication and wear response in compromised tissues. In
addition, we used animal models to investigate exogenous and
endogenous tribosupplementation of lubricin, which provide insight
into the treatment of degenerative joint diseases.
In this dissertation, we show that lubricin is vital to
boundary lubrication and the preservation of joint health at both
the structural and cellular levels. Furthermore, we show that
tribosupplementation provides joint lubrication and prevents
apoptosis of chondrocytes in lubricin deficient disease models.
The major findings in this dissertation support further
investigation of lubricin as a tribosupplenent in large animal
preclinical models and in patients with genetic or acquired
lubricin deficiency, who have unmet medical needs. Furthermore,
this work provides insight into the mechanopathway relating
friction and apoptosis, which provides groundwork for additional
therapeutic targets in the prevention of biological
wear.
Advisors/Committee Members: Jay, Gregory (Director), Crisco, Joseph (Reader), Darling, Eric (Reader), Fleming, Braden (Reader), Elsaid, Khaled (Reader).
Subjects/Keywords: lubricin
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Waller, K. A. (2013). Preventing Biological Wear in the Synovial Joint: The Role
of Lubricin as a Boundary Lubricant and Tribosupplement. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:320659/
Chicago Manual of Style (16th Edition):
Waller, Kimberly A. “Preventing Biological Wear in the Synovial Joint: The Role
of Lubricin as a Boundary Lubricant and Tribosupplement.” 2013. Doctoral Dissertation, Brown University. Accessed April 20, 2021.
https://repository.library.brown.edu/studio/item/bdr:320659/.
MLA Handbook (7th Edition):
Waller, Kimberly A. “Preventing Biological Wear in the Synovial Joint: The Role
of Lubricin as a Boundary Lubricant and Tribosupplement.” 2013. Web. 20 Apr 2021.
Vancouver:
Waller KA. Preventing Biological Wear in the Synovial Joint: The Role
of Lubricin as a Boundary Lubricant and Tribosupplement. [Internet] [Doctoral dissertation]. Brown University; 2013. [cited 2021 Apr 20].
Available from: https://repository.library.brown.edu/studio/item/bdr:320659/.
Council of Science Editors:
Waller KA. Preventing Biological Wear in the Synovial Joint: The Role
of Lubricin as a Boundary Lubricant and Tribosupplement. [Doctoral Dissertation]. Brown University; 2013. Available from: https://repository.library.brown.edu/studio/item/bdr:320659/
13.
Larson, Katherine Marie.
The Role of Lubricin in Mitigating Alterations to Joint
Tissues Experiencing Friction.
Degree: Biomedical Engineering, 2017, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:733398/
► This work discusses the unique tribological and anti-inflammatory properties of the glycoprotein lubricin in relation to arthritis. The first aim investigates changes in friction and…
(more)
▼ This work discusses the unique tribological and
anti-inflammatory properties of the glycoprotein lubricin in
relation to arthritis. The first aim investigates changes in
friction and lubricin gene expression in inflamed bovine cartilage
explants lubricated with saline or recombinant human lubricin
compared to control explants. This study informs us that exogenous
human lubricin may provide therapeutic value to inflamed cartilage
through decreasing friction. The second aim uncovers how cell
adhesion molecules are affected in lubricin null synoviocytes and
provides results on metabolic biomarkers for lubricin null
conditions. Lubricin null synoviocytes were found to have decreased
ICAM-1 and cadherin-11 surface protein compared to control cells,
which is linked to increased proliferation and decreased organized
cellular condensation respectively. Furthermore, lubricin null
synoviocytes were found to have increased VCAM-1 surface protein
and lubricin null mice were found to have increased deoxyglucose
accumulation in hind limb inter phalangeal joints compared to
control cells and mice, suggesting VCAM-1 and deoxyglucose may be
biomarkers for synoviocyte hyperplasia and pannus-like formation in
lubricin null mice. The results of this study also suggest that the
lubricin null condition may be crucial in understanding arthritis
progression and developing novel preventative treatments for
arthritic diseases. The third aim provides insight into the
metabolomics of friction, in relation to lubricin expression. For
this study Prg4 transgenic mice, that are lubricin null at birth
and whose alleles can be recombined after tamoxifen injection to
allow for normal lubricin expression, were assessed. Mice
recombined at 7 and 14 days after birth were assessed along with
mice that had not been recombined (lubricin null mice) and two
phenotypically normal groups of mice (mice heterozygous and mice
homozygous for lubricin expression). It was found that both
recombined mouse groups displayed increased friction over time and
osteoarthritis damage scores similar to lubricin null mice,
suggesting little to no restoration of lubricated joint mechanics.
Markers for mitochondrial dysregulation and oxidative stress were
significantly improved for both recombined mouse groups compared to
lubricin null mice, suggesting restoration of normal joint
metabolism.
Advisors/Committee Members: Darling, Eric (Reader), Elsaid, Khaled (Reader), Tripathi, Anubhav (Reader), Jay, Gregory (Advisor), Fleming, Braden (Reader), Crisco, Joseph (Reader).
Subjects/Keywords: Osteoarthritis
Record Details
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Larson, K. M. (2017). The Role of Lubricin in Mitigating Alterations to Joint
Tissues Experiencing Friction. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:733398/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Larson, Katherine Marie. “The Role of Lubricin in Mitigating Alterations to Joint
Tissues Experiencing Friction.” 2017. Thesis, Brown University. Accessed April 20, 2021.
https://repository.library.brown.edu/studio/item/bdr:733398/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Larson, Katherine Marie. “The Role of Lubricin in Mitigating Alterations to Joint
Tissues Experiencing Friction.” 2017. Web. 20 Apr 2021.
Vancouver:
Larson KM. The Role of Lubricin in Mitigating Alterations to Joint
Tissues Experiencing Friction. [Internet] [Thesis]. Brown University; 2017. [cited 2021 Apr 20].
Available from: https://repository.library.brown.edu/studio/item/bdr:733398/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Larson KM. The Role of Lubricin in Mitigating Alterations to Joint
Tissues Experiencing Friction. [Thesis]. Brown University; 2017. Available from: https://repository.library.brown.edu/studio/item/bdr:733398/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
14.
Hopkins, Paul Robert.
Examining Therapeutic Hypothermia as a Treatment for
Traumatic Brain Injury using a 3D In Vitro Collagen Model.
Degree: Biomedical Engineering, 2017, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:733362/
Subjects/Keywords: traumatic brain injury
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hopkins, P. R. (2017). Examining Therapeutic Hypothermia as a Treatment for
Traumatic Brain Injury using a 3D In Vitro Collagen Model. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:733362/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hopkins, Paul Robert. “Examining Therapeutic Hypothermia as a Treatment for
Traumatic Brain Injury using a 3D In Vitro Collagen Model.” 2017. Thesis, Brown University. Accessed April 20, 2021.
https://repository.library.brown.edu/studio/item/bdr:733362/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hopkins, Paul Robert. “Examining Therapeutic Hypothermia as a Treatment for
Traumatic Brain Injury using a 3D In Vitro Collagen Model.” 2017. Web. 20 Apr 2021.
Vancouver:
Hopkins PR. Examining Therapeutic Hypothermia as a Treatment for
Traumatic Brain Injury using a 3D In Vitro Collagen Model. [Internet] [Thesis]. Brown University; 2017. [cited 2021 Apr 20].
Available from: https://repository.library.brown.edu/studio/item/bdr:733362/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hopkins PR. Examining Therapeutic Hypothermia as a Treatment for
Traumatic Brain Injury using a 3D In Vitro Collagen Model. [Thesis]. Brown University; 2017. Available from: https://repository.library.brown.edu/studio/item/bdr:733362/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
. 
Open Access Theses and Dissertations