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You searched for +publisher:"Brown University" +contributor:("Bungiro, Richard"). One record found.

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1. Toussaint, Leon E. Invariant Natural Killer T Cell Development is Uniquely Regulated by Y-Chromosome Genes and SHIP-1.

Degree: PhD, Pathobiology, 2012, Brown University

The Src homology 2 (SH2) domain-containing inositol-5-phosphatase 1 (SHIP-1) plays a critical role in regulating the phosphoinositide 3-kinases (PI3Ks) signaling pathway. PI3Ks are important for the development, differentiation and function of lymphocyte and myeloid cells, and SHIP-1 has been implicated in the function, development and maintenance of these cells. However a clear impact of SHIP-1 on the invariant natural killer T (iNKT) cell population has yet to be investigated. iNKT cells are a unique subset of T lymphocytes which share some characteristics with mainstream T cells, but have distinct functions and a separate development program. Due to this divergence from the conventional T cell developmental program, many factors specific to iNKT cell development and function have been discovered. Our current studies delve further into factors that influence the iNKT cell population. In chapter 2, by Investigation of a unique Y-chromosome mutation we explore the development iNKT cells in relation to Y-linked genes. The use of targeted breeding strategies and microarray analysis allowed for the discovery of four Y-linked genes that may possibly play an essential role in iNKT cells development. In chapter 3 of this dissertation we also look at the influence of SHIP-1 on the iNKT cell population in mice and by extensive examinations of the T lymphocyte compartments we reveal an undiscovered global T lymphocyte requirement of SHIP-1. Although many past studies have revealed factors such as signal transduction and transcription factors, cytokines and surface molecules that influence iNKT cell development and function there has never been a study which explored the impact of Y-linked genes or SHIP-1 on iNKT cells. Advisors/Committee Members: Brossay, Laurent (Director), Reichner, Jonathan (Reader), Gregory, Stephen (Reader), Bungiro, Richard (Reader), Boyaka, Prosper (Reader).

Subjects/Keywords: Y-linked genes

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APA (6th Edition):

Toussaint, L. E. (2012). Invariant Natural Killer T Cell Development is Uniquely Regulated by Y-Chromosome Genes and SHIP-1. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:297571/

Chicago Manual of Style (16th Edition):

Toussaint, Leon E. “Invariant Natural Killer T Cell Development is Uniquely Regulated by Y-Chromosome Genes and SHIP-1.” 2012. Doctoral Dissertation, Brown University. Accessed October 13, 2019. https://repository.library.brown.edu/studio/item/bdr:297571/.

MLA Handbook (7th Edition):

Toussaint, Leon E. “Invariant Natural Killer T Cell Development is Uniquely Regulated by Y-Chromosome Genes and SHIP-1.” 2012. Web. 13 Oct 2019.

Vancouver:

Toussaint LE. Invariant Natural Killer T Cell Development is Uniquely Regulated by Y-Chromosome Genes and SHIP-1. [Internet] [Doctoral dissertation]. Brown University; 2012. [cited 2019 Oct 13]. Available from: https://repository.library.brown.edu/studio/item/bdr:297571/.

Council of Science Editors:

Toussaint LE. Invariant Natural Killer T Cell Development is Uniquely Regulated by Y-Chromosome Genes and SHIP-1. [Doctoral Dissertation]. Brown University; 2012. Available from: https://repository.library.brown.edu/studio/item/bdr:297571/

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