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You searched for +publisher:"Boston University" +contributor:("Stern, Robert A."). Showing records 1 – 2 of 2 total matches.

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Boston University

1. Carpenter, Sydney Blake. Characterizing a symptom profile in former athletes.

Degree: MS, Medical Sciences, 2019, Boston University

The long-term effects of repetitive head impacts are a growing concern. Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease that is associated with repetitive head impacts and is characterized by distinct neuropathological changes. Other risk factors of developing CTE are still unknown but may include age, genetics, age of first exposure to sports and type of sport. The only way to diagnose CTE is with a post-mortem analysis. Current research is focused on diagnosing CTE during life; efforts are turning towards developing a clinically diagnosable syndrome that is related to CTE prognosis. Common symptoms reported from retrospective analyses of CTE confirmed cases include cognitive difficulties as well as mood and behavior symptoms like depression and impulsivity. The goal of the present study was to define the clinical presentation of a diverse group of former athletes in an effort to categorize a clinical presentation of individuals with various head impact exposure. The individuals in the sample included contact and non-contact sport athletes, both male and female, ranging from 19 to 86 years of age. The data was based on a larger study, the Longitudinal Examination to Gather Evidence of Neurodegenerative Disease (LEGEND). In a sample of 592 participants from this study, cluster analyses identified five discrete groups of individuals based on their symptom profile. These included Asymptomatic, Mildly symptomatic, Mood symptoms, Behavior symptoms and Highly symptomatic groups. Between the groups, there was no difference in age of participants. There was no prevalence of a certain sport in any of the clusters. Additionally, there was no significant finding regarding estimated number of head impacts and symptomatology in football players. Results showed an effect of cognitive reserve, measured by years of education. Participants in the Asymptomatic group had significantly more education. This implies that years of education may be a risk factor for decreasing one’s ability to cope with neuropathology. Further research needs to be done on the connection between symptomatology and neuropathological diagnosis. Advisors/Committee Members: Stern, Robert A. (advisor).

Subjects/Keywords: Neurosciences; Brain; Concussion; CTE; Sports

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Carpenter, S. B. (2019). Characterizing a symptom profile in former athletes. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/36263

Chicago Manual of Style (16th Edition):

Carpenter, Sydney Blake. “Characterizing a symptom profile in former athletes.” 2019. Masters Thesis, Boston University. Accessed January 16, 2021. http://hdl.handle.net/2144/36263.

MLA Handbook (7th Edition):

Carpenter, Sydney Blake. “Characterizing a symptom profile in former athletes.” 2019. Web. 16 Jan 2021.

Vancouver:

Carpenter SB. Characterizing a symptom profile in former athletes. [Internet] [Masters thesis]. Boston University; 2019. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/2144/36263.

Council of Science Editors:

Carpenter SB. Characterizing a symptom profile in former athletes. [Masters Thesis]. Boston University; 2019. Available from: http://hdl.handle.net/2144/36263


Boston University

2. Duncan, Kristen Marie. Characterizing the incidence of sleep disorders in a cohort of former college football players.

Degree: MS, Medical Sciences, 2020, Boston University

CTE is a progressive neurodegenerative disease defined by p-tau lesions in characteristic locations of the brain, leading to cognitive impairment as well as mood and behavioral dysfunction. Exposure to repetitive head impacts is a major risk factor for developing CTE; however, additional risk factors and secondary modulating factors, which may expand available treatment and prevention options, are still being elucidated. Studies into the glymphatic system, a system of waste clearance in the brain thought to be activated during sleep, have implicated glymphatic dysfunction in the clearance of toxic proteins like amyloid-beta and hyperphosphorylated tau, as well as in cognitive decline in neurodegenerative disorders like Alzheimer’s Disease, bringing into question whether sleep, through impacting glymphatic clearance, may act as a modulating factor in the development of CTE. In the present study, we began to characterize the presence of sleep disorders and their co-morbid conditions in a cohort of former college football players to gain better insight into their prevalence and the health outcomes of those with sleep conditions. Our results found higher rates of sleep apnea in the study sample, as well as an association between diagnosis with sleep apnea and diagnosis with dementia, AD, MCI, CTE, and similar disorders. Sleep apnea was significantly associated with depression, anxiety, high cholesterol, and diabetes. Further research into whether sleep disorders exacerbate CTE pathology or clinical symptoms, and whether treatment of sleep symptoms leads to better outcomes for patients with CTE, is necessary to further elucidate a potential connection. Advisors/Committee Members: Stern, Robert A. (advisor), Alosco, Michael (advisor).

Subjects/Keywords: Neurosciences; Chronic traumatic encephalopathy; CTE; Dementia; Insomnia; Repetitive head impacts; Sleep disorders

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Duncan, K. M. (2020). Characterizing the incidence of sleep disorders in a cohort of former college football players. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/41216

Chicago Manual of Style (16th Edition):

Duncan, Kristen Marie. “Characterizing the incidence of sleep disorders in a cohort of former college football players.” 2020. Masters Thesis, Boston University. Accessed January 16, 2021. http://hdl.handle.net/2144/41216.

MLA Handbook (7th Edition):

Duncan, Kristen Marie. “Characterizing the incidence of sleep disorders in a cohort of former college football players.” 2020. Web. 16 Jan 2021.

Vancouver:

Duncan KM. Characterizing the incidence of sleep disorders in a cohort of former college football players. [Internet] [Masters thesis]. Boston University; 2020. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/2144/41216.

Council of Science Editors:

Duncan KM. Characterizing the incidence of sleep disorders in a cohort of former college football players. [Masters Thesis]. Boston University; 2020. Available from: http://hdl.handle.net/2144/41216

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