Full Record

New Search | Similar Records

Author
Title Efeitos do fitoterápico Tribulus terrestris sobre a próstata do gerbilo da Mongólia (Meriones unguiculatus) : Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus): Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus)
URL
Publication Date
Date Accessioned
University/Publisher Universidade Estadual de Campinas
Abstract Abstract: The plant Tribulus terrestris (TT) is used to treat numerous health problems in many traditional medicines. One of the most frequent indication of use is for the treatment of sexual dysfunction, because of its supposed ability to interfere with androgenic metabolism. Because of this, TT became popular among individuals of various ages, having been used as a natural and legal alternative for anabolics. However, the use of substances that interfere with hormonal balance can have negative consequences for prostate histophysiology, since the prostate is an organ that is the target of androgen action and sensitive to hormonal changes. On the other hand, data from the literature indicate a possible chemoprotective action of some of the major components of TT, the saponins, which would be able to attenuate deleterious effects of age and exposure to toxic agents. Thus, this work has proposed to present an extensive review of the literature on the role of this herbal medicine in aspects of reproductive biology (Chapter I) and to evaluate the effects of the use of TT extract on testosterone levels and its consequences on the histophysiology of the prostate in intact Mongolian gerbil, or those exposed to the carcinogen N-methyl-N-nitrosourea (MNU). To evaluate the effects of short-term exposure (Chapter II), 24 males were divided into four groups: experimental control, control of carcinogenic induction (50 mg/kg of MNU in a single dose on the 180º day), control of TT effects (11 mg/kg, in daily doses from 180º to 270º day) and treatment after induction (11 mg/kg of TT, in daily doses from 180º to 270º day, after a single dose of 50 mg/kg of MNU on the 180º day). To evaluate the effects of long-term exposure (Chapter III), 24 males were divided into four groups: experimental control, carcinogenic induction control (50 mg/kg MNU, in a single dose on the 180º day), control of prolonged use of TT (11 mg/kg in daily doses from 90º to 270º day) and prolonged treatment associated with induction (11 mg/kg of TT, in daily doses from 90º to 270º day, with a single dose of 50 mg/kg of MNU on the 180º day). TT was not able to raise serum testosterone levels and did not cause biometric changes in androgen-sensitive organs, which indicates low anabolic potential at the dose and periods administered. In addition, the herbal medicine may have contributed to the chemoprotection of the prostate as it has delayed the onset of malignant lesions in the gland. There was a specific action of TT in reducing the activity of the canonical androgenic pathway (decrease of androgen receptors and proliferation of epithelial cells), reproducing, in vivo, the protection against the tumor activity already observed in vitro. However, in spite of repressing the onset of malignant lesions, TT was not able to prevent the onset of premalignant lesions, especially when the use started in young individuals. Thus, the effects of TT on the prostate need to be better understood and phytotherapeutic use still requires caution
Subjects/Keywords Tribulus terrestris; Prostata; Cancer - Quimioprevenção; Gerbilos; Testosterona; Tribulus terrestris; Prostate; Cancer - Chemoprevetion; Gerbils; Testosterone
Contributors UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP); Taboga, Sebastião Roberto (advisor); Santos, Fernanda Cristina Alcântara dos (coadvisor); Universidade Estadual de Campinas. Instituto de Biologia (institution); Programa de Pós-Graduação em Biologia Celular e Estrutural (nameofprogram); Borges, Luciano de Figueiredo (committee member); Augusto, Taize Machado (committee member); Oliveira, Silvia Borges Pimentel de (committee member); Delella, Flavia Karina (committee member)
Language multilíngua
Country of Publication br
Record ID oai:repositorio.unicamp.br:REPOSIP/332303
Repository unicamp
Date Indexed 2020-09-09
Issued Date 2017-01-01 00:00:00
Note [] Orientadores: Sebastião Roberto Taboga, Fernanda Cristina Alcântara dos Santos; [] Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia; [degreelevel] Doutorado; [degreediscipline] Biologia Celular; [degreename] Doutor em Biologia Celular e Estrutural; [sponsordocumentnumber] 2014/26660-0; [sponsordocumentnumber] 305840/2015-0; [sponsor] FAPESP; [sponsor] CNPQ;

Sample Images

.