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Title Hiponatremia e alterações do fator natriurético atrial em pacientes neurocirúrgicos: Hyponatremia and atrial natriuretic factor alterations in neurosurgical patients
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Date Accessioned
University/Publisher Universidade Estadual de Campinas
Abstract Abstract: Hyponatremia is the electrolyte imbalance most often found in patients with neurological disorders and is associated with significant morbidity and mortality. The Cerebral Salt Wasting Syndrome, defined as renal sodium loss, polyuria and hyponatremia in neurological patients, has been considered as the main responsible for hyponatremia in these patients. The pathogenesis of the Cerebral Salt Wasting Syndrome is not yet fully understood, but seems to involve a natriuretic factor. OBJECTIVE: To evaluate the alterations of atrial natriuretic factor and your correlation with hyponatremia and natriurese present in neurosurgical patients. METHODS: We studied 30 patients undergoing resection of intracranial tumor and brain aneurysm clipping. Blood and urine samples (12hour urine) were obtained preoperatively and daily from the first to the fifth postoperative days for determination of plasma and urinary sodium, in addition to preoperative blood samples, first, third and fifth postoperative days for determination of atrial natriuretic factor by Radioimmunoassay. RESULTS: Hyponatremia was present at 63.33% of patients, particularly in the first postoperative day. Natriurese was observed in 93.33% of patients, mainly in the second postoperative day. Plasmatic atrial natriuretic factor were increased in 92.60% of patients in at least one of the postoperative days. However there are no statistically significant correlations between atrial natriuretic factor and serum sodium, neither between atrial natriuretic factor and the urinary sodium. CONCLUSION: Hyponatremia and natriuresis are present in the most of patients after neurosurgery, however ANF cannot be considered to be directly responsible for these alterations in neurosurgical patients and another natriuretic factor should be involved in it
Subjects/Keywords Sódio; Hiponatremia; Natriurese; Fator natriurético atrial; Neurocirurgia; Sodium; Hyponatremia; Natriuresis; Atrial natriuretic factor; Neurosurgery
Contributors UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP); Dragosavac, Desanka, 1951- (advisor); Falcão, Antonio Luis Eiras, 1959- (coadvisor); Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution); Programa de Pós-Graduação em Ciências da Cirurgia (nameofprogram); Figueiredo, Luciana Castilho de (committee member); Avelar, Wagner Mauad (committee member); Basile Filho, Anibal (committee member); Guedes, Cristina Aparecida Veloso (committee member)
Language português
Country of Publication br
Record ID oai:repositorio.unicamp.br:REPOSIP/331218
Repository unicamp
Date Indexed 2020-09-09
Issued Date 2017-01-01 00:00:00
Note [] Orientadores: Desanka Dragosavac, Antonio Luis Eiras Falcão; [] Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas; [degreelevel] Doutorado; [degreediscipline] Pesquisa Experimental; [degreename] Doutora em Ciências; [sponsordocumentnumber] 2000/05990-9; [sponsor] FAPESP;

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…RESUMO Hiponatremia o distrbio eletroltico mais frequentemente encontrado em pacientes com doenas neurolgicas e est associada com significante morbimortalidade. A Sndrome Perdedora de Sal, definida como perda renal de sdio, poliria e…

hiponatremia em pacientes neurolgicos, tem sido considerada como a principal responsvel pela hiponatremia nestes pacientes. A patognese da Sndrome Perdedora de Sal ainda no completamente entendida, porm parece envolver ao de algum fator natriurtico…

…OBJETIVO: Avaliar as alteraes do fator natriurtico atrial e sua correlao com a hiponatremia e natriurese presentes em pacientes neurocirrgicos. MTODOS: Foram estudados 30 pacientes submetidos resseco de tumor intracraniano e clipagem de…

…primeiro, terceiro e quinto dias ps-operatrios para dosagem do fator natriurtico atrial atravs de radioimunoensaio. RESULTADOS: Hiponatremia esteve presente em 63,33% dos pacientes, particularmente no primeiro dia ps-operatrio. Natriurese foi…

…estatisticamente significante entre o fator natriurtico atrial e o sdio plasmtico, nem entre o fator natriurtico atrial e o sdio urinrio. CONCLUSO: Hiponatremia e natriurese esto presentes na maioria dos pacientes neurocirrgicos caracterizando uma Sndrome…

…Perdedora de Sal. Contudo, o fator natriurtico atrial no pde ser considerado como o responsvel direto por tais alteraes e um outro fator natriurtico deve estar envolvido. PALAVRAS-CHAVE: Sdio; Hiponatremia; Natriurese; Fator natriurtico atrial…

…16 1.1.Hiponatremia .................................................................................................. 16 1.1.1. Sdio e regulao de lquidos ................................................................... 16 1.1.2. Quadro…

…manifestaes clnicas so primariamente neurolgicas podendo alterar o volume celular, aumentar a presso intracraniana e piorar a condio neurolgica e prognstico destes pacientes. 1-8 Dos distrbios de sdio, a hiponatremia o distrbio mais comumente…

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