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Title The impact of inflammatory and immune response-related genetic variants on prostate cancer risk among men of African descent.
Publication Date
Degree MS
Degree Level masters
University/Publisher University of Louisville
Abstract Background: In the U.S., prostate cancer (PCA) metastasis is associated with a 5-yr survival rate of 29% and disproportionately affects men of African descent. Single nucleotide polymorphisms (SNPs) may serve as genetic markers to identify individuals at high risk of developing PCA. Methods: We examined main and joint effects of 119 inflammatory and immune response-associated SNPs among men of African descent (535 controls, 279 cases) via logistic regression (LR) and entropy-based-multi-factor dimensionality reduction (MDR) modeling. Results: MDR yielded highly synergistic [(TLR10, TLR6 and IRF3), (TLR2, IRAK4), (IL1R2, IL10, IL10RA)] interaction models as the best predictors of PCA risk based upon informative information gain scores (p ≤ 0.003). Interestingly, CCL5 [rs2107538 (AA, GA+AA), rs3817655 (GA, AA)] SNPs were strongly associated with a 43-56% decrease in PCA risk. <strong>Conclusion: </strong>CCL5 (rs2107538 ,rs3817655) reduces PCA risk by > 50% and may serve as potential targets of PCA treatment among men of African descent.
Subjects/Keywords Oncology
Contributors Kidd, LaCreis; Clark, Geoffrey; Barve, Shirsh; Gobeshijvili, Leila; Klinge, Carolyn
Record ID oai:ir.library.louisville.edu:etd-2746
Repository louisville
Date Retrieved
Date Indexed 2018-06-27
Created Date 2014-12-01 08:00:00

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