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Title Fatty Acid Desaturase (FADS) Genetic Variants and Dietary Polyunsaturated Fatty Acid Intake: Associations with Negative Affect
Publication Date
Degree PhD
Discipline/Department Psychology
Degree Level doctoral
University/Publisher The Ohio State University
Abstract Background: Depressive symptomatology has been associated with polyunsaturated fatty acid (PUFA) levels in diet and tissue. However, results have been mixed, and studies have failed to account for genetic factors that may influence such associations. Tissue PUFA levels are strongly influenced by elongase and desaturase activity, which are governed by the fatty acid desaturase (FADS) genes. Inefficient desaturase activity has been associated with depression. Further, FADS genotypes have been associated with neuropsychological phenotypes such as postpartum depression. Given these associations, the study of relationships among dietary PUFA intake, FADS genotype, and mood symptoms is warranted. Aims: The present study investigated associations among dietary intake of PUFAs, the rs174575 polymorphism of the fatty acid desaturase (FADS2) gene, and psychological outcomes. The primary aim was to determine if FADS2 genotype interacts with omega-3 (n-3) and omega-6 (n-6) PUFA dietary intake to influence associations with depressive symptoms, anxiety symptoms, anger, hostility, neuroticism, or optimism. Methods: A sample of 172 female undergraduate students provided genetic material from buccal cells, and completed a food frequency questionnaire and self-report measures including the Center for Epidemiological Studies Depression Scale, PROMIS Anxiety and Anger Scales, Cook Medley Hostility Scale, NEO Neuroticism Scale, and LOT-R Optimism Scale. Results: The main finding was that higher n-3 intake was associated with greater hostility. However, n-3 intake was not related to depressive symptoms, anxiety, anger, neuroticism, or optimism, nor was n-6 intake. Further, genotype did not interact with PUFA intake for any psychological outcomes. Conclusion: This study provided no evidence that the rs174575 fatty acid desaturase polymorphism influences associations between PUFA intake and mood.
Subjects/Keywords Psychology; rs174575; FADS; PUFA; omega-3 fatty acids; polyunsaturated fatty acids; gene x environment interaction; mood; women's health
Contributors Kiecolt-Glaser, Janice (Advisor)
Language en
Rights unrestricted ; This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
Country of Publication us
Format application/pdf
Record ID oai:etd.ohiolink.edu:osu1333466271
Repository ohiolink
Date Indexed 2016-12-22
Grantor The Ohio State University

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