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Title Interactive Effect of the Serotonin Transporter 5-HTTLPR Genotype and Chronic Stress on Depressive Symptoms in Postmenopausal Women
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Publication Date
Degree MA
Discipline/Department Psychology
Degree Level masters
University/Publisher The Ohio State University
Abstract The short (s) allele of the serotonin transporter gene length polymorphism (5-HTTLPR) is associated with depression when combined with stress, in a gene by environment interaction model. This research examined the relationship between the 5-HTTLPR gene and caregiving stress on symptoms of depression in postmenopausal women. The sample included 105 female controls and 79 female dementia caregivers. Depressive symptomatology was assessed with the Center for Epidemiologic Studies Depression Scale (CES-D). Results showed that the gene by environment interaction was not significant (p=0.167) in postmenopausal women, although there was a main effect for caregiver status, such that caregivers showed higher CES-D scores than controls (p<0.001). When comparing premenopausal women to postmenopausal women, the three-way gene by environment by menopausal status interaction was not significant (p=0.711), nor was the gene by environment interaction (p=0.140). However, there was a main effect for caregiver status such that caregivers exhibited higher CES-D scores compared to controls (p=0.003). Results suggest that postmenopausal women undergoing caregiving stress exhibit higher levels of depressive symptomatology regardless of genotype, and that female caregivers are more depressed than female controls regardless of menopausal status.
Subjects/Keywords Psychology; serotonin transporter gene; 5-HTTLPR; women's health; depression; gene x environment interaction model
Contributors Kiecolt-Glaser, Janice (Advisor)
Language en
Rights unrestricted ; This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
Country of Publication us
Format application/pdf
Record ID oai:etd.ohiolink.edu:osu1266260369
Repository ohiolink
Date Indexed 2016-12-22
Grantor The Ohio State University

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