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Title Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids
Publication Date
Date Accessioned
University/Publisher Kyoto University
Subjects/Keywords alzheimer's disease; amyloid b; catechol; flavonoid; taxifolin; autoxidation
Contributors 入江, 一浩 (advisor); 河田, 照雄 (advisor); 保川, 清 (advisor)
Language en
Rights 許諾条件により本文は2014-09-01に公開
Country of Publication jp
Record ID handle:2433/188766
Repository kyoto
Date Indexed 2018-03-09
Issued Date 2014-03-24 00:00:00

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…aggregative properties of A42 (Chapter 2). In Chapter 3, the involvement of autoxidation in the inhibitory ability of (+)-taxifolin against A42 aggregation in the presence of an oxidant or under anaerobic conditions was estimated using Th…

…catechol moiety on B-ring was suggested to be important for the anti-aggregative ability, the mechanism how the catechol moiety contributes to the activity is not fully understood. This Chapter describes a comprehensive study on the role of autoxidation of…

…aggregation by catechol-type flavonoids targeting the Lys residues. J. Biol. Chem. 2013; 288: 23212-23224. The American Society for Biochemistry and Molecular Biology. 25 Results Effects of autoxidation of (+)-taxifolin on its ability to prevent…

…the aggregation of A42 A catechol moiety is easily oxidized to form an o-quinone.92,93) To investigate the contribution of autoxidation to the inhibitory ability, the author examined the aggregative ability of A42 in the presence of (+)…

…NaIO4 could partially oxidize Met35 in the monomeric A42, but not the fibrils. Furthermore, in order to investigate the role of autoxidation, the effect by (+)-taxifolin on A42 aggregation was tested in vacuo. Notably, (+)-taxifolin…

…aggregated in the presence of (+)-taxifolin and tris(2-carboxy-ethyl)phosphine (TCEP), a reductant (Fig. 11C). These results strongly suggest the autoxidation of (+)-taxifolin to be required for inhibitory…

…Detection of o-quinone form of (+)-taxifolin using 1,2-phenylenediamine. 28 Next, the author measured UV spectra of (+)-taxifolin incubated with A42 to evaluate the effects of NaIO4 or the anaerobic condition on the autoxidation of…

…when (+)-taxifolin and A42 were co-incubated in vacuo or with TCEP (Fig. 12B). These results indicate that the o-quinone formation in (+)-taxifolin through autoxidation plays a critical role in the inhibition of A42…