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Title Literature-based discovery of known and potential new mechanisms for relating the status of cholesterol to the progression of breast cancer
Publication Date
Date Accessioned
Degree MS
Discipline/Department Bioinformatics
Degree Level thesis
University/Publisher University of Illinois – Urbana-Champaign
Abstract Breast cancer has been studied for a long period of time and from a variety of perspectives in order to understand its pathogeny. The pathogeny of breast cancer can be classified into two groups: hereditary and spontaneous. Although cancer in general is considered a genetic disease, spontaneous factors are responsible for most of the pathogeny of breast cancer. In other words, breast cancer is more likely to be caused and deteriorated by the dysfunction of a physical molecule than be caused by germline mutation directly. Interestingly, cholesterol, as one of those molecules, has been discovered to correlate with breast cancer risk. However, the mechanisms of how cholesterol helps breast cancer progression are not thoroughly understood. As a result, this study aims to study known and discover potential new mechanisms regarding to the correlation of cholesterol and breast cancer progression using literature review and literature-based discovery. The known mechanisms are further classified into four groups: cholesterol membrane content, transport of cholesterol, cholesterol metabolites, and other. The potential mechanisms, which are intended to provide potential new treatments, have been identified and checked for feasibility by an expert.
Subjects/Keywords Literature-based discovery; literature review; breast cancer; cholesterol; mechanisms
Contributors Torvik, Vetle I (advisor); Nelson, Erik Russell (advisor)
Language en
Rights Copyright 2019 Yu Wang
Country of Publication us
Record ID handle:2142/104825
Repository uiuc
Date Indexed 2020-03-09
Grantor University of Illinois at Urbana-Champaign
Issued Date 2019-04-17 00:00:00

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…intrinsic molecular-based subclasses: basal-like (BL), normal-like, luminal A, luminal B, and HER2-enriched [5]. In addition, a specific type of enzyme protein, called protein kinases, have been proven to play an important role in…

…publication Figure 1 The amount of literature focused on both cholesterol and breast cancer published to PubMed per year since 1946. The search terms were next restricted to both MeSH9 and title terms. The result from the medially restrictive PubMed search…

…restricted search terms; second, extracting the known mechanisms by which cholesterol helps the progression of breast cancer by systematically searching the literature on cholesterol and breast cancer on PubMed using the heavily restricted search term; and…

…Fields] Breast cancer [All Fields] Second, the set of literature was restricted using the medially restricted search term “("breast neoplasms"[TI] OR "breast neoplasms"[MeSH Terms]) AND…

…Stage – Literature review to identify known mechanisms In the second stage of the research project, the heavily restricted search term “"breast neoplasms"[MeSH Major Topic] AND cholesterol [MeSH Major Topic]” was used to…

…to identify potential new mechanisms Overall, the third stage of the project used a method called Literature-BasedDiscovery (LBD) to explore the correlation between cholesterol and breast cancer [18]. Unlike traditional research…

…methods, such as wet labs and clinical trials, in the biomedical domain, LBD is a relatively new way of exploring new ideas. Specifically, LBD refers to discovering new information from existing literature in either a semiautomated or automated way […

…18]. As the scientific literature in specific fields increases exponentially, interaction between/among fields might become weak, and the knowledge in a field might become isolated from the broader world of knowledge [18]. As a result…