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Title On nerve function after Orthognatic Surgery
Publication Date
University/Publisher University of Gothenburg / Göteborgs Universitet
Abstract Background Orthognathic surgery is a surgical intervention to correct dentofacial anomalies. It is a complicated treatment that involves cooperation of different specialties. The success of orthognathic surgery is multifactorial with many elements to be taken into consideration. It is estimated that about 11 patients among every 100.000 Swedish citizens are in need of orthognathic surgeries. The most common surgical procedures for correction of mandibular deformities are the sagittal split osteotomy (SSO) and vertical ramus osteotomy (VRO), which is done either with an intraoral approach (IVRO) or an Extraoral approach (EVRO). Genioplasty is also often done, sometimes combined with other orthognathic surgeries. Despite the various modifications added to these operations to enhance their performance and results, nerve injury afterwards, especially after the SSO can occur. Neurosensory disturbance (NSD) following such trauma is still the main and most common drawback after these operations. Objectives This thesis is based on five studies. The aims of the first study were to investigate the incidence of sensory changes after SSO and whether it was different between osteotomy alone and osteotomy with genioplasty and to assess the impact of sensory disturbances on patients’ satisfaction. The second study aims were to evaluate NSD after SSO and IVRO, asses the difference between questionnaire and patient’s record in evaluating the NSD and to evaluate the discomfort caused by NSD. The aim of the third study was to assess the patients’ satisfaction after EVRO and discomfort regarding sensory and motor nerve disturbances. The fourth and fifth study aimed to investigate in an experimental animal model the difference in degenerative and regenerative patterns between a sensory and a motor nerve (the Mental Nerve (MN) and the Buccal branch of Facial Nerve (BF) respectively) using an unbiased stereological technique and further to study the effect of Steroids on nerve de- and regeneration. Material and Method For the first 3 retrospective studies, questionnaires were sent to the patients. In addition, answers in the second study were checked against patients' records. Paper 4 and 5 were animal studies; MN and the BF were injured in 48 Wister rats, half of which were treated with steroids perioperatively. The injured nerves were then studied using an unbiased technique called 2D Stereology. Results No significant differences in NSD incidence were found between the patients who had osteotomy alone and those who also had genioplasty. Sensory disturbances are not a main determinant of patients’ satisfaction. There was disagreement between patients' records and questionnaire in which symptoms of long lasting NSD were underestimated by the surgeon. Only 1% had permanent NSD following EVRO although resultant scar tissue was of concern to 30% of patients involved. The regenerative process is faster and/or more complete in the facial nerve (motor function) than it is in the mental nerve (sensory function). There were an increased number…
Subjects/Keywords Orthognathic surgery; Nerve Healing; Betamethasone
Language en
Country of Publication se
Record ID handle:2077/52417
Other Identifiers 978-91-629-0342-8 (PRINT); 978-91-629-0343-5 (PDF)
Repository goteborg
Date Retrieved
Date Indexed 2018-01-11

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