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Title Predictive factors of uterine movement during definitive radiotherapy for cervical cancer : 子宮頸癌根治的放射線治療期間中の子宮移動の予測因子について
Publication Date
Degree 博士(医学)
University/Publisher University of the Ryukyus / 琉球大学
Abstract To determine the predictive factors affecting uterine movement during radiotherapy (RT), we quantified interfractionuterine movement using computed tomography (CT) and cone-beam CT (CBCT). A total of 38 patientswho underwent definitive RT for cervical cancer were retrospectively analyzed. We compared pre-RT planning CT(n = 38) and intratreatment CBCT (n = 315), measuring cervical and corporal movement in each direction. Correlations between uterine movement and volume changes of the bladder and rectum on all CBCT scans wereanalyzed using Spearman rank correlation analysis. Relationships between the mean uterine movement and patientfactors were analyzed using the Mann–Whitney test. The mean corpus movement was: superior margin (cranio–caudal direction), 7.6 ± 5.9 mm; anterior margin (anteroposterior direction), 8.3 ± 6.3 mm; left margin (lateral direction),3.3 ± 2.9mm; and right margin (lateral direction), 3.0 ± 2.3 mm. Generally, the mean values for cervicalmovement were smaller than those for the corpus. There was a significant, weak correlation between changes inbladder volume and the movement of the superior margin of the corpus (ρ = 0.364, P < 0.001). There was a significantdifference in movement of the superior margin of the corpus between the subgroups with and without ahistory of previous pelvic surgery (P = 0.007). In conclusion, change in bladder volume and a history of previoussurgery were significantly related to intrafractional corpus movement; however, our observations suggest that theaccurate prediction of uterine movement remains challenging.
Subjects/Keywords cervical cancer; radiotherapy; computed tomography; uterus; cone-beam CT
Language en
Country of Publication jp
Record ID handle:20.500.12000/36587
Repository jairo
Date Retrieved
Date Indexed 2017-06-19
Issued Date 2016-10-15 00:00:00

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