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Title Using reproducible research pipelines to help disentangle health effects of environmental changes from social factors
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University/Publisher Australian National University
Abstract The scientific questions motivating this thesis relate to the health effects of environmental changes including droughts, bushfires, woodsmoke, duststorms and heatwaves. Such questions require us to attempt to disentangle health effects of environmental changes from social factors as all diseases have multiple causal factors. Environmental exposures should be explored in the context of many other variables that comprise the biological and socioeconomic milieu. Investigators often narrow the focus to a single environmental cause and health effect. A simple example is bushfire smoke and its direct effects on cardiorespiratory disease. A more complex example is the indirect relationship between drought and suicide. Even simple questions require consideration of numerous putative causes and confounders. Adequately controlling for all these factors in statistical models is difficult. Furthermore results might be sensitive to choice of analysis procedure, or otherwise error-prone due to the many steps. Such difficulties have led to what some researchers assert is a ‘reproducibility crisis’ where many scientific publications are difficult or impossible to reproduce. This, with fallacious findings, harms scientific credibility. Reproducibility of data analysis is defined as the ability to recompute results, given a dataset and knowledge of the method’s steps. A key problem impairing reproducibility is inadequate documentation of the numerous steps and decisions required for the computations. Reproducible research pipelines allow data and software (such as analysis code) to be disseminated with publications, enhancing reproducibility. However, this approach often places a considerable burden on the analyst. This thesis identifies effective methods for implementing reproducible research pipelines in environmental epidemiology, aiming to reduce this burden. In addition to the contribution to methodology which this constitutes, the thesis also includes a range of peer reviewed papers (along with accompanying datasets and software packages of code) published by the author, which also add to knowledge. Key findings include health effects of environmental changes relevant to debates about climate change. Reproducibility of these findings enhances their credibility in response to the heightened scepticism of those debates. Important insights included the finding that the risk of suicide in New South Wales increases in rural men during drought but decreases during droughts for women. Another striking finding was that while bushfire smoke and duststorms each increased cardiorespiratory mortality risk in Sydney, they appear to do so in different ways, with dust having a much higher risk estimate than biomass smoke. In cases such as this where findings are novel, unexpected or contradict accepted…
Subjects/Keywords health effects; environmental change; drought; suicide; biomass smoke; dust; heat; cardiovascular; respiratory; infectious disease; pathogen habitat; reproducibility; reproducible research
Language en
Country of Publication au
Record ID handle:1885/108735
Repository anu
Date Retrieved
Date Indexed 2019-10-01

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