Full Record

New Search | Similar Records

Author
Title Reactivity of N-(3-hydroxyacyl)amino acids and influence of their corresponding homoserine lactones on cyclic lipopeptide production
URL
Publication Date
University/Publisher Ghent University
Abstract In this PhD thesis isotope-labelled AHLs were synthesized which can be used as a tool to study the metabolization of AHLs. Secondly, the possible rearrangement of N-(3-hydroxyacyl)- L-homoserine lactones was investigated and proven to be very unlikely. This investigation resulted in the successful development of a synthetic entry toward 1,4-oxazepane-2,5-diones, which are extremely difficult to synthesize due to the presence of a lactam with a preference for the trans-conformation and a labile lactone moiety in one ring structure. By applying the disclosed methodology on the synthesis of the natural product serratin, the incorrect structural assignment of this compound was identified. Thirdly, the profound effect of a QS signal molecule, HO8, on the swarming behavior of Pseudomonas species CMR12a, was demonstrated. This influence goes presumably via an elegant fine-tuning of the ratio of the two produced CLPs, orfamide and sessilin via the control of orfamide production.
Subjects/Keywords Chemistry
Contributors Mangelinckx, Sven; De Kimpe, Norbert; Stevens, Christian
Language en
Rights I have retained and own the full copyright for this publication ; info:eu-repo/semantics/openAccess
Country of Publication be
Format application/pdf
Record ID handle:1854/LU-8543529
Other Identifiers urn:isbn: 9789463570695
Repository ghent
Date Retrieved
Date Indexed 2020-04-26

Sample Images

.