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Title Acoustic wave biosensor arrays for the simultaneous detection of multiple cancer biomarkers
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Date Accessioned
Degree PhD
Discipline/Department Electrical and Computer Engineering
Degree Level doctoral
University/Publisher Georgia Tech
Abstract The analysis and development of robust sensing platforms based on solidly-mounted ZnO bulk acoustic wave devices was proposed. The exploitation of acoustic energy trapping was investigated and demonstrated as a method to define active sensing areas on a substrate. In addition, a new "hybrid" acoustic mode experiencing acoustic energy trapping was studied theoretically and experimentally. This mode was used as an explanation of historical inconsistencies in observed thickness-shear mode velocities. Initial theoretical and experimental results suggest that this mode is a coupling of thickness-shear and longitudinal particle displacements and, as such, may offer more mechanical and/or structural information about a sample under test. Device development was taken another step further and multi-mode ZnO resonators operating in the thickness-shear, hybrid, and longitudinal modes were introduced. These devices were characterized with respect to sample viscosity and conductivity and preliminary results show that, with further development, the multi-mode resonators provide significantly more information about a sample than their single-mode counterparts. An alternative to resonator-based platforms was also presented in the form of bulk acoustic delay lines. Initial conceptual and simulation results show that these devices provide a different perspective of typical sensing modalities by using properly designed input pulses, device tuning, and examining overall input and output signal spectra.
Subjects/Keywords ZNO; Bulk acoustic wave; Energy trapping; Acoustic sensors; Biosensors; Bulk acoustic delay line; SMR; Biosensors; Biochemical markers; Tumor markers; Acoustic surface wave devices
Contributors Hunt, William (Committee Chair); Kenney, J. Stevenson (Committee Chair); Ballato, Arthur (Committee Member); Hertling, David (Committee Member); Taylor, David (Committee Member)
Country of Publication us
Record ID handle:1853/42717
Repository gatech
Date Indexed 2018-01-11
Issued Date 2011-08-11 00:00:00
Note [degree] PhD; [advisor] Committee Chair: Hunt, William; Committee Chair: Kenney, J. Stevenson; Committee Member: Ballato, Arthur; Committee Member: Hertling, David; Committee Member: Taylor, David;

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