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Title In-silico Study of Trans-rectal Computed Tomography for External and Internal Imaging Geometry
Publication Date
Date Accessioned
Discipline/Department Electrical Engineering
University/Publisher Oklahoma State University
Abstract This work investigates a complete forward and inverse model of thermo-acoustic computed tomography (TACT) for the reconstruction of electrical conductivity distribution within an external and internal imaging geometry. The external imaging geometry that resembles a geometry used for the breast cancer detection and the internal imaging geometry that resembles a geometry used for the prostate cancer detection is illuminated by an electromagnetic (EM) source at a microwave frequency and the generated acoustic wave within the geometry due to EM illumination is detected by an array of ultrasonic transducers. From the detected acoustic wave, the absorbed energy density profile within the geometry and hence the electrical conductivity which is directly related to the energy density is reconstructed. It has been well proved that cancerous tissue exhibits different conductivity profile from normal tissue due to different concentration of ions and water in the cancerous tissue. As a result of this, cancerous tissue absorbs microwave energy differently and a reconstructed image based on an absorbed microwave energy density or conductivity profile can give a precise location of the cancerous tissue. A finite element method (FEM) based complete reconstruction algorithm is investigated and various simulated reconstructed images based on different conductivity profile between cancerous and normal tissue are shown.
Subjects/Keywords finite element method; thermo-acoustic tomography; trans-rectal geometry
Contributors Bunting, Charles (advisor); Piao, Daqing (committee member); West, James C. (committee member); Santhanakrishnan, Arvind (committee member)
Language en
Rights Copyright is held by the author who has granted the Oklahoma State University Library the non-exclusive right to share this material in its institutional repository. Contact Digital Library Services at [email protected] or 405-744-9161 for the permission policy on the use, reproduction or distribution of this material.
Country of Publication us
Record ID handle:11244/15031
Repository okstate
Date Indexed 2018-01-03
Issued Date 2013-12-01 00:00:00
Note [department] Electrical Engineering;

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…3 1.3 Schematic illustration of thermo-acoustic phenomenon ..........................................5 1.4 External imaging geometry ....................................................................................11 1.5 Internal or trans-rectal…

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…contrast images of cancerous tissues. Both DOT and microwave imaging provide high contrast images but suffer from low resolution. Thermo-acoustic computed tomography (CT), also known as Microwave-induced thermoacoustic tomography (MI-TAT)…

…or simply thermo-acoustic tomography (TAT) is an emerging medical imaging modality that combines both microwave and ultrasound imaging [5, 8] to provide a high-contrast and high-resolution images of cancerous cells. This…

…image reconstruction algorithm. 2 Figure 1.1 Mammographic image of breast tumor [13]. A B Figure 1.2.A Ultrasonic image of breast cyst [14]. Figure 1.2.B Ultrasonic image of Prostate cancer [17]. 3 1.2. Thermo

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…absorption of the microwave energy causes a thermo-elastic expansion of the tissues which in turn results in transient pressure rise inside the tissues. This rise in pressure propagates as an acoustic wave that originates from the location of the microwave…

…Microwave-induced thermo-acoustic tomography (MI-TAT) exploits this different energy absorption characteristic to reveal a contrast between malignant and normal tissues, as having been manifested for breast cancer detection [5, 8] and…