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Title HAEMOPHILUS INFLUENZAE AND MORAXELLA CATARRHALIS INTRA- AND INTERSPECIES QUORUM SIGNALING
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Publication Date
Date Accessioned
University/Publisher Wake Forest University
Abstract Otitis media (OM) is among the most common childhood diseases worldwide. OM infections often persist for long periods of time and can be highly resistant to antibiotic treatment due in part to persistence of bacteria within biofilms. The majority of OM infections also involve coinfection by multiple species. For instance, the leading causative agents <italic>Haemophilus influenzae</italic> and <italic>Moraxella catarrhalis</italic> are more frequently found to coexist than to be isolated individually. Polymicrobial infection and biofilm formation may have a dramatic impact on the severity and treatability of OM. Thus, there is a pressing need to investigate polymicrobial infection and to identify factors that contribute to the establishment of these infections. One factor that may contribute to the establishment of polymicrobial infection is bacterial communication via quorum signaling. Autoinducer-2 (AI-2) is termed an interspecies signal as the genetic determinant for AI-2 production (<italic>luxS</italic>) is highly conserved and many species possess the machinery to respond to AI-2. <italic>H. influenzae</italic> has a <italic>luxS</italic> homolog whereas <italic>M. catarrhalis</italic> does not but may still sense and respond to AI-2. Therefore, the focus of this project was to investigate the impact of AI-2 intra- and interspecies bacterial communication and <italic>H. influenzae</italic> and <italic>M. catarrhalis</italic> polymicrobial infection on biofilm formation, antibiotic resistance, and persistence in experimental OM.
Subjects/Keywords Autoinducer 2
Language en
Country of Publication us
Record ID handle:10339/33430
Repository wfu
Date Retrieved
Date Indexed 2019-01-18
Issued Date 2011-01-01 00:00:00

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…anginosus V. harveyi Vibrio harveyi V. cholerae Vibrio cholerae viii A. actinomycetemcomitans Aggregatibacter actinomycetemcomitans luxS gene encoding the AI-2 synthase AI-2 autoinducer-2 DPD (S)-4,5-dihydroxy-2,3-pentanedione, AI-2…

…precursor Lsr LuxS regulated AHL/HSL acyl homoserine lactones, autoinducer-1 AIP autoinducer peptide PCho phosphorylcholine LOS lipooligosaccharide LPS lipopolysaccharide EPS extracellular polymeric substances, exopolysaccharide OM otitis…

…bacterial communication via quorum signaling. Autoinducer-2 (AI-2) is termed an interspecies signal as the genetic determinant for AI-2 production (luxS) is highly conserved and many species possess the machinery to respond to AI-2. H…

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